AJP - Renal Physiology, Vol 233, Issue 2 73-F81, Copyright © 1977 by American Physiological Society

ARTICLES

Neurogenic regulation of renal tubular sodium reabsorption

G. F. DiBona

The evidence supporting a role for direct neurogenic control of renal tubular sodium reabsorption is reviewed. Electron microscopic and fluorescence histochemical studies have demonstrated adrenergic nerve terminals in direct contact with basement membranes of mammalian (rat, dog, and monkey) renal tubular epithelial cells. Low-level direct or baroreceptor reflex stimulation of renal sympathetic nerves produces an increase in renal tubular sodium reabsorption without alterations in glomerular filtration rate, renal blood flow, or intrarenal distribution of blood flow. Antinatriuresis was prevented by prior treatment of the kidney with guanethidine or phenoxybenzamine. Rat kidney micropuncture studies have localized a site of enhanced tubular sodium reabsorption to the proximal tubule. Possible indirect mediation of the antinatriuresis by other humoral agents known to be released from the kidney on renal nerve stimulation (angiotensin II, prostaglandin) was excluded by experiments with appropriate blocking agents. The possible effects of anesthesia and uncertainties about the completeness of surgical renal denervation and other tubular segmental sites of action are critically analyzed. The clinical implications of this mechanism in pathologic conditions of sodium and water retention are discussed and and a prospectus for future work is presented.

This article has been cited by other articles:

				C. W. Bourque, S. Ciura, E. Trudel, T. J. E. Stachniak, and R. Sharif-Naeini Hydromineral Neuroendocrinology: Neurophysiological characterization of mammalian osmosensitive neurones Exp Physiol, May 1, 2007; 92(3): 499 - 505. [Abstract] [Full Text] [PDF]

				T. E. N. Jonassen, L. Brond, M. Torp, M. Grabe, S. Nielsen, O. Skott, N. Marcussen, and S. Christensen Effects of renal denervation on tubular sodium handling in rats with CBL-induced liver cirrhosis Am J Physiol Renal Physiol, March 1, 2003; 284(3): F555 - F563. [Abstract] [Full Text] [PDF]

				A. Quan and M. Baum The renal nerve is required for regulation of proximal tubule transport by intraluminally produced ANG II Am J Physiol Renal Physiol, March 1, 2001; 280(3): F524 - F529. [Abstract] [Full Text] [PDF]

				T. Yamasaki, M. Ohmagari, I. Tamai, K. Hayashi, and Y. Matsumura Inhibitory Effects of AE0047, a New Dihydropyridine Ca2+ Channel Blocker, on Renal Nerve Stimulation-Induced Renal Actions in Anesthetized Dogs J. Pharmacol. Exp. Ther., June 1, 2000; 293(3): 1040 - 1047. [Abstract] [Full Text]

				S. Abdulnour-Nakhoul, R. N. Khuri, and N. L. Nakhoul Effect of norepinephrine on intracellular pH in kidney proximal tubule: role of Na+-(HCO-3)n cotransport Am J Physiol Renal Physiol, July 1, 1998; 275(1): F33 - F45. [Abstract] [Full Text] [PDF]

				R. Veelken, K. F. Hilgers, A. Stetter, H.-G. Siebert, R. E. Schmieder, and J. F.E. Mann Nerve-Mediated Antidiuresis and Antinatriuresis After Air-Jet Stress Is Modulated by Angiotensin II Hypertension, November 1, 1996; 28(5): 825 - 832. [Abstract] [Full Text]

				A. Quan and M. Baum Renal nerve stimulation augments effect of intraluminal angiotensin II on proximal tubule transport Am J Physiol Renal Physiol, June 1, 2002; 282(6): F1043 - F1048. [Abstract] [Full Text] [PDF]