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Am J Physiol Renal Physiol 233: F298-F306, 1977;
0363-6127/77 $5.00
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AJP - Renal Physiology, Vol 233, Issue 4 298-F306, Copyright © 1977 by American Physiological Society

ARTICLES

Mechanism of active chloride secretion by shark rectal gland: role of Na-K-ATPase in chloride transport

P. Silva, J. Stoff, M. Field, L. Fine, J. N. Forrest and F. H. Epstein

The isolated rectal gland of Squalus acanthias was stimulated to secrete chloride against an electrical and a chemical gradient when perfused in vitro by theophylline and/or dibutyryl cyclic AMP. Chloride secretion was depressed by ouabain which inhibits Na-K-ATPase. Thiocyanate and furosemide also inhibited chloride secretion but ethoxzolamide, a carbonic anhydrase inhibitor, did not. Chloride transport was highly dependent on sodium concentration in the perfusate. The intracellular concentration of chloride averaged 70-80 meq/liter in intact glands, exceeding the level expected at electrochemical equilibrium and suggesting active transport of chloride into the cell. These features suggest a tentative hypothesis for chloride secretion by the rectal gland in which the uphill transport of chloride into the cytoplasm is coupled through a membrane carrier to the downhill movement of sodium along its electrochemical gradient. The latter is maintained by the Na-K-ATPase pump while chloride is extruded into the duct by electrical forces.


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