AJP - Renal Physiology, Vol 244, Issue 5 516-F525, Copyright © 1983 by American Physiological Society
Renal response to four hours of biliary obstruction in the dog
M. Levy and H. Finestone
Clearance studies were performed in anesthetized dogs before and 4 h after
the acute obstruction of the common bile duct (ABDL). ABDL was not
associated with any change in systemic hemodynamics or plasma volume.
Glomerular filtration rate (GFR) rose by 15.3%, PAH clearance by 13.3%, and
renal blood flow by 13% (all values significant at P less than 0.05).
Fractional excretion rates of water and sodium rose from 0.29 to 1.1 and
from 0.21 to 0.76%, respectively (P less than 0.05). These changes in renal
function were associated with a failure of bile excretion rather than
distension of the biliary tree or failure of bile to enter the duodenum.
They did not depend on intact hepatic nerves, alteration of hepatic
perfusion, or the release of gastrointestinal vasoactive peptides. The
increment in renal perfusion was maintained for 2-3 days before returning
to baseline levels. Several lines of evidence suggested that factors
influencing the renal tubule and the renal microcirculation might be
separate in nature: e.g., urinary sodium excretion (UNaV) could increase
without a change in GFR; if ABDL was relieved, delta UNaV and delta GFR
returned to base line with different time courses; and controlling
perfusion to the left kidney during ABDL reduced but did not abolish the
increase in UNaV. Both effects could be transferred to recipient dogs by
cross-perfusion. We have demonstrated, therefore, that 4 h of ABDL may
significantly influence renal function through the appearance of humoral
factors in the circulation.
