AJP - Renal Physiology, Vol 245, Issue 1 75-F82, Copyright © 1983 by American Physiological Society
Angiotensin in the hemodynamic response to chronic nephron obstruction
P. K. Carmines and G. A. Tanner
Microsphere techniques were employed to investigate the role of intrarenal
angiotensin generation in producing the arteriolar constriction associated
with 24-h tubular obstruction in rats. In each animal, glomerular blood
flow (GBF) and nephron vascular resistance were determined for normal and
oil-blocked superficial cortical nephrons. In 17 control rats, GBF of
normal and blocked nephrons averaged 226 +/- 12 and 130 +/- 9 nl/min,
respectively (P less than 0.001). Captopril treatment in five rats (10
mg/kg orally) improved GBF to blocked nephrons to 252 +/- 31 nl/min.
Saralasin treatment in six rats (10 micrograms . kg-1 . min-1 i.v.)
lessened the difference between GBF of normal and obstructed nephrons. In
six rats subjected to a high salt intake and deoxycorticosterone
injections, GBF to obstructed nephrons was improved to 181 +/- 21 nl/min.
Since both pharmacologic interruption of angiotensin activity and renin
suppression were associated with improved GBF of blocked nephrons, these
observations support a role for angiotensin as a local factor controlling
glomerular hemodynamics of chronically obstructed nephrons.
