AJP - Renal Physiology, Vol 245, Issue 2 223-F226, Copyright © 1983 by American Physiological Society
Effect of glucocorticoids on renal net glucose release in vivo in normal and diabetic rats
F. Kamiya, H. Kimura, T. Takeuchi, K. Kida and H. Nakagawa
The effect of glucocorticoids on renal net glucose release in vivo in
normal and diabetic rats was studied by the isotope-dilution method.
Administration of hydrocortisone to normal fed rats increased renal net
glucose release from 0.93 +/- 0.25 to 2.27 +/- 0.21 mg . dl-1 . min-1 and
increased its contribution to blood glucose from 27.0 +/- 4.5 to 46.6 +/-
4.0%. The renal net glucose release and its contribution to blood glucose
in adrenalectomized rats were 0.40 +/- 0.06 mg . dl-1 . min-1 and 16.3 +/-
1.4%, respectively, significantly less than those of normal control rats,
and these parameters were raised to the levels of normal control rats by
the administration of hydrocortisone. In rats with streptozotocin-induced
diabetes, the renal net glucose release and its contribution to blood
glucose were significantly increased to 2.22 +/- 0.51 mg . dl-1 . min-1 and
46.7 +/- 4.9%, respectively, and these parameters were normalized by
adrenalectomy. These data indicate that glucocorticoids play an important
role in regulation of renal net glucose release and its contribution to
blood glucose in both normal and diabetic rats.
