AJP - Renal Physiology, Vol 247, Issue 4 539-F542, Copyright © 1984 by American Physiological Society
Sinoaortic baroreceptors and the control of blood volume in the nonhuman primate
K. G. Cornish, T. McCulloch and J. P. Gilmore
The purpose of this study was to determine the role of the aortic and
carotid baroreceptors in regulating blood volume in the conscious non-human
primate. Eighteen control animals were surgically instrumented to permit
the recording of blood pressure, pulse rate, and left atrial pressure.
After a urethral catheter was inserted into the bladder, the animals were
given an intravenous infusion equal to 20% of the estimated blood volume.
Renal function was determined before and after the volume expansion. Nine
monkeys received the same infusion after undergoing chronic sinoaortic
denervation. The denervated animals responded with a potentiated diuresis
and natriuresis. The control animals excreted 24% of the infused volume and
4% of the infused salt while the sinoaortic-denervated animals excreted a
volume equal to 113% of that infused and an amount of sodium equal to 46%
of that infused. We conclude that high-pressure receptors exert an
inhibitory influence on whatever mechanisms are involved in the renal
response to acute volume expansion.
