AJP - Renal Physiology, Vol 248, Issue 2 206-F211, Copyright © 1985 by American Physiological Society
Mechanism for inhibition of renin release by acute plasma volume expansion in the dog
M. W. Roy, C. E. Ott, W. J. Welch, J. H. Downs and T. A. Kotchen
Plasma volume expansion alters renal tubular sodium chloride transport and
renal nerve activity. The purpose of this study was to determine the
mechanism(s) for inhibition of renin secretion by acute volume expansion
with albumin in the anesthetized dog. In dogs with a single intact kidney,
albumin infusion decreased renin release by 86% and significantly increased
renal blood flow, glomerular filtration rate, and sodium excretion. Albumin
volume expansion inhibited renin secretion to a lesser extent in dogs with
denervated filtering kidneys and in dogs with innervated nonfiltering
kidneys. In dogs with denervated nonfiltering kidneys, albumin infusion did
not change renin secretion. Comparable volume expansion was produced in all
groups. Thus, inhibition of renin release by acute plasma volume expansion
is dependent on both a renal tubular mechanism and the integrity of the
renal nerves. Partial inhibition of renin release was observed with
interruption of either one of the mechanisms, whereas interruption of both
mechanisms totally abolished the effect of acute plasma volume expansion on
renin secretion.
