AJP - Renal Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 249: F324-F337, 1985;
0363-6127/85 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Brenner, B. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Brenner, B. M.

AJP - Renal Physiology, Vol 249, Issue 3 324-F337, Copyright © 1985 by American Physiological Society

ARTICLES

Nephron adaptation to renal injury or ablation

B. M. Brenner

In early stages of permanent renal injury or extensive ablation, structural and functional adaptations associated with hypertrophy partially compensate for nephron losses. Glomerulotubular balance is maintained in these conditioned nephrons by intrinsic tubule and peritubular capillary adaptations that parallel single nephron glomerular filtration rate (SNGFR). Studies of Na+-H+ exchange in renal cortical brush border membrane vesicles indicate that tubule functional adaptation is not tied to loss of renal mass per se but rather to factors such as dietary protein content that set the level of SNGFR. Likewise, the structural heterogeneity that follows chronic renal injury or extreme ablation of renal mass is less a consequence of nephron injury than of adaptation linked to dietary protein intake. Indeed, since dietary protein restriction blunts the need for compensatory glomerular hyperfiltration, there is neither a stimulus for nephron hypertrophy nor for enhanced tubule ion and fluid transport. In rats with remnant kidneys, experimentally induced diabetes mellitus, or severe hypertension, increases in glomerular pressures and flows precede proteinuria, glomerular sclerosis, and azotemia. Protein restriction prevents these hemodynamic adaptations as well as the late complications. Similar conclusions appear to be applicable to a wide spectrum of clinical circumstances characterized by reduced nephron number.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
D. H. T. IJpelaar, A. Schulz, K. Koop, M. Schlesener, J. A. Bruijn, D. Kerjaschki, R. Kreutz, and E. de Heer
Glomerular hypertrophy precedes albuminuria and segmental loss of podoplanin in podocytes in Munich-Wistar-Fromter rats
Am J Physiol Renal Physiol, April 1, 2008; 294(4): F758 - F767.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
Y. Tan, J.-S. Keum, B. Wang, M. B. McHenry, S. R. Lipsitz, and A. A. Jaffa
Targeted deletion of B2-kinin receptors protects against the development of diabetic nephropathy
Am J Physiol Renal Physiol, October 1, 2007; 293(4): F1026 - F1035.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Loria, V. Reverte, F. Salazar, F. Saez, M. T. Llinas, and F. J. Salazar
Changes in renal hemodynamics and excretory function induced by a reduction of ANG II effects during renal development
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2007; 293(2): R695 - R700.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Loria, V. Reverte, F. Salazar, F. Saez, M. T. Llinas, and F. J. Salazar
Sex and age differences of renal function in rats with reduced ANG II activity during the nephrogenic period
Am J Physiol Renal Physiol, August 1, 2007; 293(2): F506 - F510.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
F. Saez, M. T. Castells, A. Zuasti, F. Salazar, V. Reverte, A. Loria, and F. J. Salazar
Sex Differences in the Renal Changes Elicited by Angiotensin II Blockade During the Nephrogenic Period
Hypertension, June 1, 2007; 49(6): 1429 - 1435.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
N. J. Hong and J. L. Garvin
Flow increases superoxide production by NADPH oxidase via activation of Na-K-2Cl cotransport and mechanical stress in thick ascending limbs
Am J Physiol Renal Physiol, March 1, 2007; 292(3): F993 - F998.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. V. Durvasula and S. J. Shankland
Mechanical strain increases SPARC levels in podocytes: implications for glomerulosclerosis
Am J Physiol Renal Physiol, September 1, 2005; 289(3): F577 - F584.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. R. R. Goncalves, C. K. Fujihara, A. L. Mattar, D. M. A. C. Malheiros, I. L. Noronha, G. de Nucci, and R. Zatz
Renal expression of COX-2, ANG II, and AT1 receptor in remnant kidney: strong renoprotection by therapy with losartan and a nonsteroidal anti-inflammatory
Am J Physiol Renal Physiol, May 1, 2004; 286(5): F945 - F954.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. K. Bidani, R. Hacioglu, I. Abu-Amarah, G. A. Williamson, R. Loutzenhiser, and K. A. Griffin
"Step" vs. "dynamic" autoregulation: implications for susceptibility to hypertensive injury
Am J Physiol Renal Physiol, July 1, 2003; 285(1): F113 - F120.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H. W. Schnaper, T. Hayashida, S. C. Hubchak, and A.-C. Poncelet
TGF-beta signal transduction and mesangial cell fibrogenesis
Am J Physiol Renal Physiol, February 1, 2003; 284(2): F243 - F252.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. Zatz, I. L. Noronha, and C. K. Fujihara
Experimental and clinical rationale for use of MMF in nontransplant progressive nephropathies
Am J Physiol Renal Physiol, December 1, 2002; 283(6): F1167 - F1175.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
A. Enomoto, M. Takeda, A. Tojo, T. Sekine, S. H. Cha, S. Khamdang, F. Takayama, I. Aoyama, S. Nakamura, H. Endou, et al.
Role of Organic Anion Transporters in the Tubular Transport of Indoxyl Sulfate and the Induction of its Nephrotoxicity
J. Am. Soc. Nephrol., July 1, 2002; 13(7): 1711 - 1720.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Krepinsky, A. J. Ingram, L. James, H. Ly, K. Thai, D. C. Cattran, J. A. Miller, and J. W. Scholey
17beta -Estradiol Modulates Mechanical Strain-induced MAPK Activation in Mesangial Cells
J. Biol. Chem., March 8, 2002; 277(11): 9387 - 9394.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
N. A. BOBADILLA, I. TACK, E. TAPIA, L. G. SANCHEZ-LOZADA, J. SANTAMARIA, F. JIMENEZ, L. J. STRIKER, G. E. STRIKER, and J. HERRERA-ACOSTA
Pentosan Polysulfate Prevents Glomerular Hypertension and Structural Injury Despite Persisting Hypertension in 5/6 Nephrectomy Rats
J. Am. Soc. Nephrol., October 1, 2001; 12(10): 2080 - 2087.
[Abstract] [Full Text] [PDF]

Home page
 PediatricsHome page
T. S. Hornung, C. G.E.L. de Goede, C. O'Brien, N. E. Moghal, J. H. Dark, and J. J. O'Sullivan
Renal Function After Pediatric Cardiac Transplantation: The Effect of Early Cyclosporin Dosage
Pediatrics, June 1, 2001; 107(6): 1346 - 1350.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
V. Y. WONG, N. J. LAPING, L. C. CONTINO, B. A. OLSON, E. GRYGIELKO, and D. P. BROOKS
Gene expression in rats with renal disease treated with the angiotensin II receptor antagonist, eprosartan
Physiol Genomics, November 9, 2000; 4(1): 35 - 42.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
T. HANNKEN, R. SCHROEDER, G. ZAHNER, R. A. K. STAHL, and G. WOLF
Reactive Oxygen Species Stimulate p44/42 Mitogen-Activated Protein Kinase and Induce p27Kip1: Role in Angiotensin II-Mediated Hypertrophy of Proximal Tubular Cells
J. Am. Soc. Nephrol., August 1, 2000; 11(8): 1387 - 1397.
[Abstract] [Full Text]

Home page
 J. Am. Soc. Nephrol.Home page
K. AMANN, L. C. RUMP, A. SIMONAVICIENE, V. OBERHAUSER, S. WESSELS, S. R. ORTH, M.-L. GROSS, A. KOCH, G. W. BIELENBERG, J. P. VAN KATS, et al.
Effects of Low Dose Sympathetic Inhibition on Glomerulosclerosis and Albuminuria in Subtotally Nephrectomized Rats
J. Am. Soc. Nephrol., August 1, 2000; 11(8): 1469 - 1478.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. M. Cruzado, J. Torras, M. Riera, I. Herrero, M. Hueso, L. Espinosa, E. Condom, N. Lloberas, J. Bover, J. Alsina, et al.
Influence of nephron mass in development of chronic renal failure after prolonged warm renal ischemia
Am J Physiol Renal Physiol, August 1, 2000; 279(2): F259 - F269.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
S. NATHANSON, E. MOREAU, C. MERLET-BENICHOU, and T. GILBERT
In Utero and in Vitro Exposure to {beta}-Lactams Impair Kidney Development in the Rat
J. Am. Soc. Nephrol., May 1, 2000; 11(5): 874 - 884.
[Abstract] [Full Text]

Home page
 J. Am. Soc. Nephrol.Home page
K. A. GRIFFIN, M. M. PICKEN, M. CHURCHILL, P. CHURCHILL, and A. K. BIDANI
Functional and Structural Correlates of Glomerulosclerosis after Renal Mass Reduction in the Rat
J. Am. Soc. Nephrol., March 1, 2000; 11(3): 497 - 506.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
C. K. FUJIHARA, I. DE LOURDES NORONHA, D. M. A. C. MALHEIROS, G. R. ANTUNES, I. B. DE OLIVEIRA, and R. ZATZ
Combined Mycophenolate Mofetil and Losartan Therapy Arrests Established Injury in the Remnant Kidney
J. Am. Soc. Nephrol., February 1, 2000; 11(2): 283 - 290.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Pathol.Home page
M. Kimura, T. Suzuki, and A. Hishida
A Rat Model of Progressive Chronic Renal Failure Produced by Microembolism
Am. J. Pathol., October 1, 1999; 155(4): 1371 - 1380.
[Abstract] [Full Text] [PDF]

Home page
 Arch. Dis. Child.Home page
H Maxwell and L Rees
Randomised controlled trial of recombinant human growth hormone in prepubertal and pubertal renal transplant recipients
Arch. Dis. Child., December 1, 1998; 79(6): 481 - 487.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. A. Jaffa, B. S. Miller, S. A. Rosenzweig, P. S. Naidu, V. Velarde, and R. K. Mayfield
Bradykinin induces tubulin phosphorylation and nuclear translocation of MAP kinase in mesangial cells
Am J Physiol Renal Physiol, December 1, 1997; 273(6): F916 - F924.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
J. C. Rodriguez-Perez, A. Losada, A. Anabitarte, J. Cabrera, J. Llobet, L. Palop, and C. Plaza
Effects of the Novel Multiple-Action Agent Carvedilol on Severe Nephrosclerosis in Renal Ablated Rats
J. Pharmacol. Exp. Ther., October 1, 1997; 283(1): 336 - 344.
[Abstract] [Full Text]

Home page
 HypertensionHome page
C. Baylis, L. Samsell, L. Racusen, and W. Gladfelter
Hypothalamic Lesions Induce Obesity and Sex-Dependent Glomerular Damage and Increases in Blood Pressure in Rats
Hypertension, April 1, 1996; 27(4): 926 - 932.
[Abstract] [Full Text]

Home page
 NEJMHome page
R. G. Narins and P. Cortes
The Role of Dietary Protein Restriction in Progressive Azotemia
N. Engl. J. Med., March 31, 1994; 330(13): 929 - 930.
[Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online