AJP - Renal Physiology, Vol 250, Issue 1 32-F39, Copyright © 1986 by American Physiological Society
Renal hemodynamics and arterial pressure during chronic intrarenal adenosine infusion in conscious dogs
J. E. Hall and J. P. Granger
The major aim of this study was to examine the chronic effects of increased
intrarenal adenosine (ADO) levels on control of renal hemodynamics and mean
arterial pressure (MAP). In six uninephrectomized conscious dogs,
intrarenal ADO infusion (2 micrograms . kg-1 . min-1) for 6 days caused no
significant changes in MAP, which averaged 94 +/- 3 mmHg during the control
period and 91 +/- 2 mmHg during ADO infusion. ADO infusion for 6 days
decreased glomerular filtration rate (GFR) and filtration fraction while
causing no significant changes in effective renal plasma flow (ERPF) or
sodium and water balance. To examine the role of angiotensin II (ANG II) in
altering the blood pressure and renal effects of ADO, we also studied the
effects of intrarenal ADO infusion in five uninephrectomized conscious dogs
during continuous intrarenal infusion of ANG II (1 ng . kg-1 . min-1) to
prevent renal levels of ANG II from decreasing. However, even when renal
ANG II levels were maintained constant, ADO infusion at 2 micrograms . kg-1
. min-1 for 4 days and 10 micrograms . kg-1 . min-1 for 5 days failed to
alter MAP, which averaged 104 +/- 6 mmHg during the control period, 106 +/-
5 mmHg during infusion of 2 micrograms . kg-1 . min-1, and 105 +/- 5 mmHg
during infusion of 10 micrograms. . kg-1 . min-1 ADO. Intrarenal ANG II
infusion did not prevent decreases in GFR and filtration fraction during
ADO infusion.(ABSTRACT TRUNCATED AT 250 WORDS)
