AJP - Renal Physiology, Vol 250, Issue 1 97-102, Copyright © 1986 by American Physiological Society
Effect of indomethacin on papillary solute concentration in the potassium-deficient rat
Y. Takamitsu and R. T. Kunau Jr
Administration of indomethacin or meclofenamate to normal rats increases
renal papillary solute concentration primarily by enhancing solute
addition. A reduction in papillary solute concentration is characteristic
of potassium deficiency. Of the multiple factors probably responsible for
this reduction, several can be influenced by indomethacin or meclofenamate.
The present study examined the effect of indomethacin on papillary solute
concentration in the potassium-deficient rat. Indomethacin increased
papillary solute concentration in normal but not potassium-deficient rats
when studied in the conscious hydropenic state. Since indomethacin could
increase papillary plasma flow in the potassium-deficient rat, potentially
negating any enhancement of solute transport into the papilla, papillary
plasma flow and papillary Cl concentration were determined in anesthetized
surgically manipulated rats. Base-line papillary Cl concentrations were
reduced in this setting. Indomethacin increased papillary plasma flow only
in potassium-deficient rats but increased papillary Cl concentration
equivalently in normal and potassium-deficient rats. The ability of
indomethacin to increase papillary solute concentration in the
potassium-deficient rat seemingly depends upon the experimental setting.
