AJP - Renal Physiology, Vol 250, Issue 5 834-F837, Copyright © 1986 by American Physiological Society
Postischemic ATP-MgCl2 provides precursors for resynthesis of cellular ATP in rats
M. E. Stromski, K. Cooper, G. Thulin, M. J. Avison, K. M. Gaudio, R. G. Shulman and N. J. Siegel
Postischemic administration of ATP-MgCl2 is known to enhance recovery of
renal function and accelerate the restitution of cellular ATP levels. To
differentiate between a direct and indirect effect of the exogenous
nucleotide, rats were subjected to 45 min of bilateral renal ischemia and
were infused with either ATP-MgCl2, AMP-MgCl2, or normal saline. The
immediate recovery of the cellular ATP was similar in all three groups of
animals, whereas the subsequent recovery was accelerated by the infusion of
either nucleotide. Since ATP-MgCl2 and AMP-MgCl2 produced similar results,
this study provides evidence that exogenous ATP may act by providing
precursors for the resynthesis of the cellular adenine nucleotide pool
rather than being a direct source of energy.
