AJP - Renal Physiology, Vol 251, Issue 6 1049-F1054, Copyright © 1986 by American Physiological Society
Renal effects of atrial natriuretic factor in primate
J. J. Bourgoignie, G. Gavellas and K. H. Hwang
Baboons (Papio hamadryas) were infused intravenously with a nonhypotensive
dose (0.1 microgram X min-1 X kg-1) of synthetic human atriopeptin III
(ANF) for 60 min. Throughout the infusion in intact animals, ANF
significantly increased glomerular filtration rate (GFR) (clearance of
inulin) (P less than 0.001), and, to a lesser extent, total renal plasma
flow (RPF) [clearance of p-aminohippurate (PAH)] (P less than 0.02) and
filtration fraction (P less than 0.02). Concomitant increases in urinary
flow rate and in the excretion of osmoles, sodium, chloride, potassium,
phosphorus, and calcium were highly significant (less than 0.001 for all).
To minimize the hemodynamic impact of ANF on GFR, the same dose of ANF was
infused into the same animals 8 wk after uninephrectomy. Base-line
single-kidney GFR was then 50% increased. With ANF infusion RPF increased
significantly (P less than 0.02), as in intact baboons, but ANF then had
only marginally significant effects on GFR (P = 0.06) and insignificant
effects on filtration fraction (P = 0.17). Nevertheless, the changes in
urinary flow rate and solute excretion rates were highly significant (P
less than 0.001 to less than 0.007). In both groups, all changes developed
rapidly, were sustained during the infusion of ANF, and were readily
reversible within 15 to 30 min of cessation of ANF infusion. The data
dissociate in uninephrectomized primate the effects of ANF on water and
solute excretion from those on GFR and filtration fraction. Both in intact
and in uninephrectomized baboons, the changes in water and solute excretion
were associated with small but significant changes in RPF.
