AJP - Renal Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 253: F158-F163, 1987;
0363-6127/87 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Baylis, C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Baylis, C.

AJP - Renal Physiology, Vol 253, Issue 1 158-F163, Copyright © 1987 by American Physiological Society

ARTICLES

Renal effects of cyclooxygenase inhibition in the pregnant rat

C. Baylis

Experiments were performed to investigate the effects of acute cyclooxygenase inhibition on renal hemodynamics in mid and late pregnant rats. In micropuncture studies in the control state, midterm pregnant rats exhibited increased single-nephron glomerular rate (SNGFR) and no change in glomerular or arterial blood pressures. In late pregnancy, SNGFR was no longer significantly elevated, glomerular pressure was similar, and arterial pressure was depressed compared with the virgin. Cyclooxygenase inhibition led to significant increases in single-nephron and whole-kidney filtration and flow in mid and late pregnant rats. This effect was also seen in the virgin control group, and all groups involved a selective renal vasodilation without change in blood pressure. In the absence of anesthesia and surgical stress, cyclooxygenase inhibition had little effect in virgin or pregnant chronically catheterized rats. These studies indicate that the cyclooxygenase-dependent arachidonic acid metabolites are not the agents directly responsible for the gestational rise in the glomerular filtration rate.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
M. A. Cadnapaphornchai, M. Ohara, K. G. Morris Jr., M. Knotek, B. Rogachev, T. Ladtkow, E. P. Carter, and R. W. Schrier
Chronic NOS inhibition reverses systemic vasodilation and glomerular hyperfiltration in pregnancy
Am J Physiol Renal Physiol, April 1, 2001; 280(4): F592 - F598.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
K. P. Conrad, R. E. Gandley, T. Ogawa, S. Nakanishi, and L. A. Danielson
Endothelin mediates renal vasodilation and hyperfiltration during pregnancy in chronically instrumented conscious rats
Am J Physiol Renal Physiol, May 1, 1999; 276(5): F767 - F776.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
L.A. Danielson and K.P. Conrad
Prostaglandins Maintain Renal Vasodilation and Hyperfiltration During Chronic Nitric Oxide Synthase Blockade in Conscious Pregnant Rats
Circ. Res., December 1, 1996; 79(6): 1161 - 1166.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online