AJP - Renal Physiology, Vol 254, Issue 1 32-F37, Copyright © 1988 by American Physiological Society
Renal nerves in exaggerated water and sodium excretion by hypertrophied kidney of anesthetized rats
G. Szenasi, G. Kottra, P. Bencsath and L. Takacs
Second Department of Medicine, Semmelweis University Medical School, Budapest, Hungary.
The effect of acute renal denervation (RD) on water (V), sodium (UNaV), and
potassium excretion (UKV) from the hypertrophied and control kidney was
studied in 5-sec-butyl-5-ethyl-2-thiobarbituric acid (Inactin)-anesthetized
male rats 7 days after unilateral nephrectomy (Nx) or sham operation (SNx).
V, UNaV, and UKV from the hypertrophied kidney were similar before and
after RD or sham RD. In contrast, in SNx rats, left RD resulted in an
ipsilateral increase in V (from 2.76 +/- 0.39 to 5.31 +/- 0.99
microliters.min-1.g-1), UNaV (from 109 +/- 36 to 857 +/- 331
nmol.min-1.g-1), and UKV (from 144 +/- 44 to 807 +/- 130 nmol.min-1.g-1; P
less than 0.05 in all cases). Moreover, renal parameters from the
hypertrophied kidney, subjected to either RD or sham RD, were not different
from values after RD in SNx rats (V: Nx, sham RD = 5.72 +/- 1.10; Nx, RD =
5.23 +/- 0.66; SNx, RD = 5.31 +/- 0.99 microliters.min-1.g-1; UNaV: Nx,
sham RD = 896 +/- 319; Nx, RD = 821 +/- 262; SNx, RD = 857 +/- 331
nmol.min-1.g-1; UKV: Nx, sham RD = 782 +/- 127; Nx, RD = 860 +/- 82; SNx,
RD = 807 +/- 130 nmol.min-1.g-1). In additional experiments, integrated
renal nerve activity (RNA) to the kidney in Nx and SNx rats was 4.0 +/- 0.3
and 10.7 +/- 0.9 microV (P less than 0.05), respectively.(ABSTRACT
TRUNCATED AT 250 WORDS)
