AJP - Renal Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 255: F1091-F1097, 1988;
0363-6127/88 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ortola, F. V.
Right arrow Articles by Brenner, B. M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ortola, F. V.
Right arrow Articles by Brenner, B. M.

AJP - Renal Physiology, Vol 255, Issue 6 1091-F1097, Copyright © 1988 by American Physiological Society

ARTICLES

Endogenous ANP augments fractional excretion of Pi, Ca, and Na in rats with reduced renal mass

F. V. Ortola, B. J. Ballermann and B. M. Brenner
Renal Division, Brigham and Women's Hospital, Boston, Massachusetts.

Atrial natriuretic peptide (ANP) infusion increases fractional excretion of many solutes including sodium, chloride, bicarbonate, phosphate, calcium, and magnesium. Because fractional excretion of these solutes increases with advancing renal disease, and because plasma ANP levels are known to be elevated in chronic renal failure, we sought to determine whether ANP mediates increased solute excretion rates per nephron in rats following extensive renal ablation, a model of chronic renal failure. Because sodium restriction decreases plasma ANP levels in the setting of reduced renal mass, we also determined the effect of sodium restriction on sodium, phosphate, calcium, and magnesium excretion rates in rats with 5/6 nephrectomy (NX). We also assessed whether high endogenous ANP levels influence fractional sodium, phosphate, calcium, and magnesium excretion in rats with 5/6 NX, by inhibiting ANP action via infusion of a high-affinity ANP antiserum. Whole-kidney glomerular filtration rate in 5/6 NX rats averaged approximately one-third that of shams, and plasma ANP levels were significantly elevated in these rats above those of shams, but to a lesser extent in rats on low- vs. high-salt intakes. Fractional sodium, phosphate, and calcium, but not magnesium excretion rates were significantly greater in 5/6 NX rats on the higher sodium intake compared with those in 5/6 NX rats on the lower sodium intake. Moreover, in 5/6 NX rats on the higher sodium intake, ANP antiserum significantly reduced fractional sodium, phosphate, and calcium excretion, but was without effect on magnesium excretion. These data implicate endogenous ANP in promoting the adaptive increase in sodium, phosphate, calcium, but not magnesium excretion per nephron in chronic renal disease.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
D. L. Vesely
Natriuretic peptides and acute renal failure
Am J Physiol Renal Physiol, August 1, 2003; 285(2): F167 - F177.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
M. KASAHARA, M. MUKOYAMA, A. SUGAWARA, H. MAKINO, T. SUGANAMI, Y. OGAWA, M. NAKAGAWA, K. YAHATA, M. GOTO, R. ISHIBASHI, et al.
Ameliorated Glomerular Injury in Mice Overexpressing Brain Natriuretic Peptide with Renal Ablation
J. Am. Soc. Nephrol., September 1, 2000; 11(9): 1691 - 1701.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
P. L. Zhang, H. S. Mackenzie, K. Totsune, J. L. Troy, and B. M. Brenner
Renal Effects of High-Dose Natriuretic Peptide Receptor Blockade in Rats With Congestive Heart Failure
Circ. Res., December 1, 1995; 77(6): 1240 - 1245.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online