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AJP - Renal Physiology, Vol 255, Issue 6 1225-F1229, Copyright © 1988 by American Physiological Society
ARTICLES |
T. L. Pallone and R. L. Jamison
Division of Nephrology, Stanford University, California 94305.
To elucidate the role of the ureter in urinary concentration we studied the effect of partial and complete ureteral excision on urinary osmolality and papillary interstitial osmolality and on sodium, potassium, and urea concentrations in the antidiuretic rat. Urine and descending vasa recta (DVR) plasma samples were obtained by micropuncture of the left renal papilla before (period 1) and 45 min after (period 2) complete (group 1, n = 10 rats) or partial (group 2, n = 10 rats) ureteral excision. Urine osmolality fell from 2,063 +/- 156 (mean +/- SE) to 736 +/- 116 mosmol/kgH2O after complete ureteral excision (P less than 0.01). After partial ureteral excision, the fall was less than half as great, from 2,038 +/- 167 to 1,551 +/- 162 mosmol/kgH2O (P less than 0.01). Vasa recta plasma osmolality decreased from 1,742 +/- 133 to 860 +/- 119 mosmol/kgH2O after complete excision (P less than 0.01) but only from 1,830 +/- 146 to 1,504 +/- 154 mosmol/kgH2O after partial excision (P less than 0.05). Mean DVR plasma sodium concentration declined from 339 +/- 25 to 211 +/- 25 meq/l (P less than 0.01) in group 1 but did not change in group 2 (348 +/- 21 to 347 +/- 28 meq/l). The fraction of DVR plasma osmolality accounted for by urea decreased significantly from 0.59 +/- 0.01 to 0.46 +/- 0.02 mM/(mosmol/kgH2O) in group 1 and from 0.59 +/- 0.02 to 0.49 +/- 0.03 mM/(mosmol/kgH2O) for group 2 (P less than 0.01, both groups). We interpret these findings to show that the remnant ureter moderates the fall in interstitial osmolality at least in part through preservation of the corticomedullary sodium chloride gradient.
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W. Zhang and A. Edwards A model of glucose transport and conversion to lactate in the renal medullary microcirculation Am J Physiol Renal Physiol, January 1, 2006; 290(1): F87 - F102. [Abstract] [Full Text] [PDF]
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W. Zhang and A. Edwards Theoretical effects of UTB urea transporters in the renal medullary microcirculation Am J Physiol Renal Physiol, October 1, 2003; 285(4): F731 - F747. [Abstract] [Full Text] [PDF]
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T. L. Pallone, M. R. Turner, A. Edwards, and R. L. Jamison Countercurrent exchange in the renal medulla Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2003; 284(5): R1153 - R1175. [Abstract] [Full Text] [PDF]
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A. Edwards, M. J. Delong, and T. L. Pallone Interstitial water and solute recovery by inner medullary vasa recta Am J Physiol Renal Physiol, February 1, 2000; 278(2): F257 - F269. [Abstract] [Full Text] [PDF]
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 A. Edwards and T. L. Pallone A multiunit model of solute and water removal by inner medullary vasa recta Am J Physiol Heart Circ Physiol, April 1, 1998; 274(4): H1202 - H1210. [Abstract] [Full Text] [PDF]
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T. L. Pallone and J. M.-C. Huang Control of descending vasa recta pericyte membrane potential by angiotensin II Am J Physiol Renal Physiol, June 1, 2002; 282(6): F1064 - F1074. [Abstract] [Full Text] [PDF]
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