AJP - Renal Watch the video to see how APS reaches out to developing nations.
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 256: F165-F170, 1989;
0363-6127/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Khraibi, A. A.
Right arrow Articles by Knox, F. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Khraibi, A. A.
Right arrow Articles by Knox, F. G.

AJP - Renal Physiology, Vol 256, Issue 1 165-F170, Copyright © 1989 by American Physiological Society

ARTICLES

Effect of renal perfusion pressure on renal interstitial hydrostatic pressure in rats

A. A. Khraibi, J. A. Haas and F. G. Knox
Department of Physiology and Biophysics, Mayo Clinic and Foundation, Rochester, Minnesota 55905.

The purpose of this study was to investigate the hypothesis that changes in renal perfusion pressure may be transmitted to the renal interstitium and cause alterations in renal interstitial hydrostatic pressure and sodium excretion. A method that utilizes a chronically implanted polyethylene matrix that allows for direct continuous measurement of renal interstitial hydrostatic pressure, and agrees well with subcapsular measurement in rats, was developed. Renal interstitial hydrostatic pressure, fractional excretion of sodium, and urine flow rate were 3.0 +/- 0.3 mmHg, 0.35 +/- 0.13%, and 19.44 +/- 3.00 microliter/min, respectively, when renal perfusion pressure was 101 +/- 0.8 mmHg. When renal perfusion pressure was increased to 123 +/- 0.9 mmHg renal interstitial hydrostatic pressure, fractional excretion of sodium, and urine flow rate increased significantly to 5.8 +/- 0.6 mmHg, 1.29 +/- 0.29%, and 50.76 +/- 8.83 microliter/min, respectively, in anesthetized male Sprague-Dawley rats. These changes occur despite a well-autoregulated glomerular filtration rate and renal blood flow. In conclusion, increasing renal perfusion pressure caused a significant increase in renal interstitial hydrostatic pressure as measured directly by the implanted polyethylene matrix method and was associated with a significant increase in sodium excretion.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
A. A. Khraibi
Renal interstitial hydrostatic pressure and pressure natriuresis in pregnant rats
Am J Physiol Renal Physiol, August 1, 2000; 279(2): F353 - F357.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
J. M. Gross, J. E. Dwyer, and F. G. Knox
Natriuretic Response to Increased Pressure Is Preserved With COX-2 Inhibitors
Hypertension, November 1, 1999; 34(5): 1163 - 1167.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online