AJP - Renal Information on EB 2010
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 256: F179-F186, 1989;
0363-6127/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Nonoguchi, H.
Right arrow Articles by Knepper, M. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Nonoguchi, H.
Right arrow Articles by Knepper, M. A.

AJP - Renal Physiology, Vol 256, Issue 1 179-F186, Copyright © 1989 by American Physiological Society

ARTICLES

ANF inhibits NaCl and fluid absorption in cortical collecting duct of rat kidney

H. Nonoguchi, J. M. Sands and M. A. Knepper
Laboratory of Kidney and Electrolyte Metabolism, National Heart, Lung, and Blood Institute, Bethesda, Maryland 20892.

Atrial natriuretic factor (ANF) is a peptide hormone that causes a large increase in urinary sodium chloride and water excretion when its plasma concentration rises above basal levels. As yet, there is no consensus regarding the chief site of action of ANF in the kidney. We microdissected and perfused rat cortical collecting ducts in vitro to determine whether ANF-(1-28) can directly inhibit net sodium and fluid absorption. ANF decreased both net sodium absorption and vasopressin-stimulated net fluid absorption by 50-90% when added to the peritubular bath solution. Approximately 50% inhibition of net fluid absorption occurred at 0.1 nM ANF, a level equivalent to plasma concentrations in volume-expanded rats. The action of ANF was mimicked by the addition of exogenous guanosine 3',5'-cyclic monophosphate. If ANF has a similar action on the cortical collecting duct in vivo, it could account for a substantial part of the ANF-mediated increase in urinary sodium and water excretion.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
J. Klokkers, P. Langehanenberg, B. Kemper, S. Kosmeier, G. von Bally, C. Riethmuller, F. Wunder, A. Sindic, H. Pavenstadt, E. Schlatter, et al.
Atrial natriuretic peptide and nitric oxide signaling antagonizes vasopressin-mediated water permeability in inner medullary collecting duct cells
Am J Physiol Renal Physiol, September 1, 2009; 297(3): F693 - F703.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
W. Wang, C. Li, L. N. Nejsum, H. Li, S. W. Kim, T.-H. Kwon, T. E. N. Jonassen, M. A. Knepper, K. Thomsen, J. Frokiaer, et al.
Biphasic effects of ANP infusion in conscious, euvolumic rats: roles of AQP2 and ENaC trafficking
Am J Physiol Renal Physiol, February 1, 2006; 290(2): F530 - F541.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
C. BAILLY
Effect of Luminal Atrial Natriuretic Peptide on Chloride Reabsorption in Mouse Cortical Thick Ascending Limb: Inhibition by Endothelin
J. Am. Soc. Nephrol., October 1, 2000; 11(10): 1791 - 1797.
[Abstract] [Full Text]

Home page
 HypertensionHome page
R. F. Husted, J. P. Rapp, and J. B. Stokes
Candidate Genes in the Regulation of Na+ Transport by Inner Medullary Collecting Duct Cells From Dahl Rats
Hypertension, February 1, 1998; 31(2): 608 - 614.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
N. H. Garcia, B. A. Stoos, O. A. Carretero, and J. L. Garvin
Mechanism of the Nitric Oxide-Induced Blockade of Collecting Duct Water Permeability
Hypertension, March 1, 1996; 27(3): 679 - 683.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online