AJP - Renal Physiology, Vol 256, Issue 5 780-F786, Copyright © 1989 by American Physiological Society
Hemodynamic, renal, and hormonal responses to incremental ANF infusions in humans
L. Groban, T. J. Ebert, D. U. Kreis, M. M. Skelton, D. M. Van Wynsberghe and A. W. Cowley Jr
Department of Anesthesiology and Physiology, Medical College of Wisconsin, Milwaukee.
The effects of incremental exogenous alpha-human atrial natriuretic factor
(ANF) infusion (10 and 25 ng.kg-1. min-1) on the cardiovascular, renal, and
hormonal systems were examined in 22 healthy males. Successive 45-min
infusions of ANF increased plasma levels five- and ninefold from a basal 42
+/- 5 pg/ml (P less than 0.01 and P less than 0.001). Hemodynamic responses
provoked by ANF consisted solely of progressive reductions in central
venous pressure (CVP) (P less than 0.05). Heart rate and mean arterial
pressure were unaltered. Plasma renin activity, aldosterone, and
vasopressin were not modified by either dose of ANF. However, plasma
norepinephrine increased 32% during the 10-ng.kg-1.min-1 infusion (P less
than 0.05) and remained elevated during the higher dose of ANF. Renal
function was unaltered by the 10-ng.kg-1.min-1 infusion of ANF when
compared with base line and placebo responses. The 25-ng.kg-1. min-1
infusion of ANF increased sodium excretion 100% from base line (P less than
0.05), whereas potassium excretion decreased 47% (P less than 0.05). Urine
output increased significantly from 7.7 +/- 0.6 to 12.5 +/- 0.7 ml/min (P
less than 0.05). These responses were not observed in the placebo group or
in an additional group of four volunteers who received a continuous
low-dose infusion of ANF (10 ng.kg-1.min-1) for two consecutive 45-min
periods. Neither dose of ANF altered creatinine clearance or free water
clearance. The data indicate that fivefold elevations (physiological
levels) of plasma ANF do not influence renal or hormonal function.(ABSTRACT
TRUNCATED AT 250 WORDS)
