AJP - Renal AJP: Gastrointestinal and Liver Physiology
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Am J Physiol Renal Physiol 257: F1094-F1099, 1989;
0363-6127/89 $5.00
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AJP - Renal Physiology, Vol 257, Issue 6 1094-F1099, Copyright © 1989 by American Physiological Society

ARTICLES

Modulation of Ca by agents affecting voltage-sensitive Ca channels in mesangial cells

Y. M. Yu, F. Lermioglu and A. Hassid
Department of Pharmacology, University of Tennessee, Memphis 38163.

The purpose of this study was to investigate the effects of depolarizing media and of Ca-channel activators and blockers on cytosolic free Ca in cultured rat mesangial cells. Membrane depolarizing media, containing 10-100 mM K+, dose dependently increased cytosolic Ca, and this effect was sustained and reversible. Nifedipine and lanthanum ion inhibited this increase, whereas verapamil was ineffective. A Ca-channel activator, BAY K 8644, dose dependently increased resting Ca levels, and nifedipine inhibited this effect. Moreover, the increase of Ca induced by maximally effective high K+ and BAY K 8644 was additive, suggesting differential mechanisms of action for the two channel activators. Nifedipine and verapamil decreased resting Ca levels by up to 35-40%. The results support the idea that mesangial cells have spontaneously active Ca channels that can be further activated by membrane depolarization or by the Ca-channel activator, BAY K 8644, and inhibited by the Ca-channel blockers, nifedipine or verapamil. Voltage-sensitive Ca channels in mesangial cells may play a role in the regulation of the glomerular filtration rate.


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