AJP - Renal AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 257: F978-F984, 1989;
0363-6127/89 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sheikh, S. P.
Right arrow Articles by Schwartz, T. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sheikh, S. P.
Right arrow Articles by Schwartz, T. W.

AJP - Renal Physiology, Vol 257, Issue 6 978-F984, Copyright © 1989 by American Physiological Society

ARTICLES

Y2-type receptors for peptide YY on renal proximal tubular cells in the rabbit

S. P. Sheikh, M. I. Sheikh and T. W. Schwartz
University Department of Clinical Chemistry, Rigshospitalet, Copenhagen, Denmark.

By means of primary cell cultures and luminal and basolateral membrane vesicles a single class of high-affinity binding sites for peptide YY (PYY), a member of the pancreatic polypeptide (PP)-fold family of peptides, was identified on the vascular side of the tubular epithelium in the proximal convoluted tubule of rabbit kidney. The binding of mono-iodinated radiolabeled PYY was inhibited equally well by PYY and neuropeptide Y (NPY), whereas the potency of the third member of the family, PP, was 10(5) times lower. Because NPY immunoreactive nerves in the mammalian kidney are confined to vascular smooth muscle cells and the juxtaglomerular apparatus, we propose that the physiological ligand for this binding site is blood-borne PYY. The kidney PYY receptor was sensitive to guanine nucleotides and could be classified as belonging to the Y2-subtype of NPY receptors, thus resembling in its binding characteristics the hippocampal NPY receptor. The high amounts of Y2-type PYY receptors present on the proximal tubule cell in rabbit kidney should permit studies on the functions and mechanisms of actions of PYY.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
C. M. Breen, P. J. Mannon, and B. A. Benjamin
Peptide YY inhibits vasopressin-stimulated chloride secretion in inner medullary collecting duct cells
Am J Physiol Renal Physiol, September 1, 1998; 275(3): F452 - F457.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
U. Holtback, Y. Ohtomo, P. Forberg, B. Sahlgren, and A. Aperia
Neuropeptide Y shifts equilibrium between alpha - and beta -adrenergic tonus in proximal tubule cells
Am J Physiol Renal Physiol, July 1, 1998; 275(1): F1 - F7.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. A. Blaze, P. J. Mannon, S. R. Vigna, A. R. Kherani, and B. A. Benjamin
Peptide YY receptor distribution and subtype in the kidney: effect on renal hemodynamics and function in rats
Am J Physiol Renal Physiol, October 1, 1997; 273(4): F545 - F553.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
G. Hallden and G. W. Aponte
Evidence for a Role of the Gut Hormone PYY in the Regulation of Intestinal Fatty Acid-binding Protein Transcripts in Differentiated Subpopulations of Intestinal Epithelial Cell Hybrids
J. Biol. Chem., May 9, 1997; 272(19): 12591 - 12600.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online