AJP - Renal Email Content Delivery
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 258: F473-F478, 1990;
0363-6127/90 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by McCarthy, R. T.
Right arrow Articles by Barrett, P. Q.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by McCarthy, R. T.
Right arrow Articles by Barrett, P. Q.

AJP - Renal Physiology, Vol 258, Issue 3 473-F478, Copyright © 1990 by American Physiological Society

ARTICLES

Atrial natriuretic peptide differentially modulates T- and L-type calcium channels

R. T. McCarthy, C. M. Isales, W. B. Bollag, H. Rasmussen and P. Q. Barrett
Miles Institute for Preclinical Pharmacology, West Haven, Connecticut 06516.

Atrial natriuretic peptide (ANP) inhibits the secretion of aldosterone stimulated by any of these major physiological agonists: angiotensin II, adrenocorticotropic hormone, or K+. The stimulatory actions of each of these agonists depend on calcium influx through voltage-dependent calcium channels. Because two types of calcium channels have been previously described in bovine glomerulosa cells (T- and L-type), the patch-clamp technique was used to evaluate the effect of ANP on each voltage-dependent calcium channel type. ANP was found to differentially modulate these two channel types, stimulating L-current while inhibiting T-current. Inhibition of T-current resulted from a shift in the voltage dependence of inactivation to more negative potentials within the physiological range. These results indicate that the ANP-induced inhibition of aldosterone secretion may be partially mediated via a reduction of the calcium current through T-type channels.


This article has been cited by other articles:


Home page
 Physiol. Rev.Home page
A. SPAT and L. HUNYADY
Control of Aldosterone Secretion: A Model for Convergence in Cellular Signaling Pathways
Physiol Rev, April 1, 2004; 84(2): 489 - 539.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
E. Perez-Reyes
Molecular Physiology of Low-Voltage-Activated T-type Calcium Channels
Physiol Rev, January 1, 2003; 83(1): 117 - 161.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
P. Q. Barrett, H.-K. Lu, R. Colbran, A. Czernik, and J. J. Pancrazio
Stimulation of unitary T-type Ca2+ channel currents by calmodulin-dependent protein kinase II
Am J Physiol Cell Physiol, December 1, 2000; 279(6): C1694 - C1703.
[Abstract] [Full Text] [PDF]

Home page
 J. Biol. Chem.Home page
J. Tao, A. Mallat, C. Gallois, S. Belmadani, P.-F. Mery, J. T.-V. Nhieu, C. Pavoine, and S. Lotersztajn
Biological Effects of C-type Natriuretic Peptide in Human Myofibroblastic Hepatic Stellate Cells
J. Biol. Chem., August 20, 1999; 274(34): 23761 - 23769.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
S. Kanwal, B. J. Elmquist, and G. J. Trachte
Atrial Natriuretic Peptide Inhibits Evoked Catecholamine Release by Altering Sensitivity to Calcium
J. Pharmacol. Exp. Ther., November 1, 1997; 283(2): 426 - 433.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online