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Am J Physiol Renal Physiol 258: F1090-F1095, 1990;
0363-6127/90 $5.00
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AJP - Renal Physiology, Vol 258, Issue 4 1090-F1095, Copyright © 1990 by American Physiological Society

ARTICLES

A micropuncture study of proximal tubular transport of lithium during osmotic diuresis

P. P. Leyssac, N. H. Holstein-Rathlou, P. Skott and A. C. Alfrey
University Institute of Experimental Medicine, Panum Institute, Copenhagen, Denmark.

Lithium and sodium are normally reabsorbed in parallel with water by the renal proximal tubule whereby their tubular fluid-to-plasma concentration ratios (TF/P) remain close to unity throughout the proximal convoluted segment. During osmotic diuresis, the late proximal (TF/P)Na is known to decrease. The present experiments were undertaken to study whether the late proximal TF/P for Li decreases like that of Na during osmotic diuresis. Data were obtained in a control period (C) and in two successive periods during mannitol diuresis (P1, P2). Glomerular filtration rate decreased gradually during osmotic diuresis [1,147 +/- 32 (C) to 950 +/- 22 (P2) microliters.min-1.g kidney wt (KW)-1, P less than 0.01), whereas Li clearance (CLi) increased [377 +/- 21 (C) to 469 +/- 28 (P1, P less than 0.01) and 408 +/- 25 (P2, NS) microliters.min-1.gKW-1, respectively]. (TF/P)Na decreased from 0.98 +/- 0.02 (C) to 0.89 +/- 0.02 (P less than 0.01) and 0.90 +/- 0.04 (P less than 0.05) (P1 and P2, respectively). (TF/P)Li was close to, but significantly higher than, unity during control (1.09 +/- 0.02), but, in contrast to (TF/P)Na, it did not decrease significantly during osmotic diuresis. Delivery of water from the proximal straight segment, as estimated from CLi/CIn, increased in proportion to the delivery from the convoluted segment, as estimated from 1/(TF/P)In. It is concluded that the proximal net Li reabsorption follows more closely the net water reabsorption than the net Na reabsorption during osmotic diuresis.


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 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. P. Leyssac, N.-H. Holstein-Rathlou, and O. Skott
Renal blood flow, early distal sodium, and plasma renin concentrations during osmotic diuresis
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2000; 279(4): R1268 - R1276.
[Abstract] [Full Text] [PDF]


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