AJP - Renal Physiology, Vol 259, Issue 2 233-F238, Copyright © 1990 by American Physiological Society
Interaction of captopril and ibuprofen on glomerular and tubular function in humans
M. Allon, C. B. Pasque and M. Rodriguez
Nephrology Section, University of Oklahoma School of Medicine, Oklahoma City.
Renal hemodynamics and tubular solute and water handling were evaluated in
normal subjects during water diuresis, before and after the acute
administration of captopril, ibuprofen, or the combination of both drugs.
The glomerular filtration increased after captopril administration but did
not change after ibuprofen alone or in combination with captopril. Renal
plasma flow increased with captopril alone and captopril plus ibuprofen but
did not change after ibuprofen alone. Urine volume and Na excretion
increased with captopril and decreased after ibuprofen; coadministration of
ibuprofen attenuated the tubular effects produced by captopril alone. FELi,
fractional delivery of solute to the distal nephron, and FELi-FENa,
fractional distal reabsorption of solute, both significantly increased
after captopril and decreased after ibuprofen but did not change with the
combined regimen. (FELi-FENa)/FELi, fractional reabsorption of distally
delivered Na, significantly decreased after captopril and increased after
ibuprofen but remained unchanged after captopril plus ibuprofen. Thus
captopril and ibuprofen have opposing effects on tubular Na and water
handling, which are attenuated by the addition of the other drug. This
interaction may have clinical relevance in patients with heart failure or
hypertension, in whom captopril is used to enhance Na and water diuresis.
