AJP - Renal Physiology, Vol 259, Issue 4 565-F572, Copyright © 1990 by American Physiological Society

ARTICLES

Restoration of tubuloglomerular feedback in volume-expanded rats by angiotensin II

J. Schnermann and J. P. Briggs
Department of Physiology, University of Michigan, Ann Arbor 48109.

Experiments were performed in anesthetized rats to examine whether angiotensin II corrects the attenuation of tubuloglomerular feedback (TGF) responses produced by acute extracellular volume expansion. Volume expansion was achieved by an infusion of isotonic saline at a rate of 9 ml/h. When urine flow had stabilized, an increase in loop of Henle flow from 0 to 45 nl/min caused a fall in stop-flow pressure (PSF) by 3.7 +/- 0.3 mmHg and in single-nephron glomerular filtration rate (SNGFR) by 5.1 +/- 1.7 nl/min. During continued saline administration angiotensin II was infused at 16, 48, or 96 ng.kg-1.min-1 while renal arterial pressure was held constant by suprarenal aortic clamping. The mean responses of PSF increased to 5.9 +/- 0.6, 9.8 +/- 0.7, and 14.9 +/- 1.7 mmHg. Angiotensin II infused at 54 ng.kg-1.min-1 increased the SNGFR response to 15.1 +/- 2.1 nl/min, whereas kidney GFR and distal SNGFR fell. Subcapsular pressure was not significantly altered by angiotensin II infusion (16 ng.kg-1.min-1). Plasma angiotensin (y, pg/ml) as a function of angiotensin II infusion rate (x, ng.kg-1.min-1 for approximately 20 min) was found to fit the function y = 2.89 + 3.53x. An infusion of approximately 15 ng.kg-1.min-1 restored plasma angiotensin levels in the volume-expanded rats to hydropenic values. These data confirm that angiotensin II may play a role as a physiological regulator of TGF sensitivity.

This article has been cited by other articles:

				A. Just Mechanisms of renal blood flow autoregulation: dynamics and contributions Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2007; 292(1): R1 - R17. [Abstract] [Full Text] [PDF]

				V. Vallon, B. Muhlbauer, and H. Osswald Adenosine and kidney function. Physiol Rev, July 1, 2006; 86(3): 901 - 940. [Abstract] [Full Text] [PDF]

				K. D. Mitchell and J. J. Mullins Enhanced tubuloglomerular feedback in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension Am J Physiol Renal Physiol, December 1, 2005; 289(6): F1210 - F1216. [Abstract] [Full Text] [PDF]

				T. Traynor, T. Yang, Y. G. Huang, J. H. Krege, J. P. Briggs, O. Smithies, and J. Schnermann Tubuloglomerular feedback in ACE-deficient mice Am J Physiol Renal Physiol, May 1, 1999; 276(5): F751 - F757. [Abstract] [Full Text] [PDF]

				K. Brannstrom and W. J. Arendshorst Resetting of exaggerated tubuloglomerular feedback activity in acutely volume-expanded young SHR Am J Physiol Renal Physiol, March 1, 1999; 276(3): F409 - F416. [Abstract] [Full Text] [PDF]

				T. Traynor, T. Yang, Y. G. Huang, L. Arend, M. I. Oliverio, T. Coffman, J. P. Briggs, and J. Schnermann Inhibition of adenosine-1 receptor-mediated preglomerular vasoconstriction in AT1A receptor-deficient mice Am J Physiol Renal Physiol, December 1, 1998; 275(6): F922 - F927. [Abstract] [Full Text] [PDF]

				L. G. Navar Integrating multiple paracrine regulators of renal microvascular dynamics Am J Physiol Renal Physiol, March 1, 1998; 274(3): F433 - F444. [Abstract] [Full Text] [PDF]

				J. Schnermann Juxtaglomerular cell complex in the regulation of renal salt excretion Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1998; 274(2): R263 - R279. [Abstract] [Full Text] [PDF]

				B. Braam, L. G. Navar, and K. D. Mitchell Modulation of Tubuloglomerular Feedback by Angiotensin II Type 1 Receptors During the Development of Goldblatt Hypertension Hypertension, June 1, 1995; 25(6): 1232 - 1237. [Abstract] [Full Text]

				G. Kovacs, J. Peti-Peterdi, L. Rosivall, and P. D. Bell Angiotensin II directly stimulates macula densa Na-2Cl-K cotransport via apical AT1 receptors Am J Physiol Renal Physiol, February 1, 2002; 282(2): F301 - F306. [Abstract] [Full Text] [PDF]