AJP - Renal AJP: Lung Cellular and Molecular Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 260: F34-F38, 1991;
0363-6127/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yamada, K.
Right arrow Articles by Yoshida, S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yamada, K.
Right arrow Articles by Yoshida, S.

AJP - Renal Physiology, Vol 260, Issue 1 34-F38, Copyright © 1991 by American Physiological Society

ARTICLES

Role of endogenous endothelin on renal functions in rats

K. Yamada and S. Yoshida
Department of Clinical Research, Sakura National Hospital, Chiba, Japan.

This study was conducted to determine the involvement of endogenous endothelin (ET), a novel potent vasoconstricting peptide, in systemic and renal hemodynamics and in the renin-angiotensin system by inhibiting ET action via infusion of a specific ET antiserum at a time of altered sodium balance. Infusion of 1:50 diluted ET antiserum, which completely inhibited renal vasoconstriction by the exogenously administered ET (0.25 to 1.0 nmol/kg), caused an increase in urinary sodium excretion and fractional excretion of sodium and a decrease in plasma renin concentration without significant changes in blood pressure, heart rate, glomerular filtration rate, renal plasma flow, and urine volume compared with the values with nonimmune serum in conscious rats fed a low-salt diet. A time control study showed no significant changes in all parameters. These results suggest that the state of low- compared to high-salt intake causes a relatively stronger activity of endogenous ET, and that the endogenous ET contributes to the adaptative modulations of sodium excretion via renal tubular action and renin release in association with the changed state of sodium balance.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
P. A. Modesti, I. Cecioni, A. Migliorini, A. Naldoni, A. Costoli, S. Vanni, and G. G. N. Serneri
Increased renal endothelin formation is associated with sodium retention and increased free water clearance
Am J Physiol Heart Circ Physiol, September 1, 1998; 275(3): H1070 - H1077.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
T. Disashi, H. Nonoguchi, T. Iwaoka, S. Naomi, Y. Nakayama, K. Shimada, K. Tanzawa, and K. Tomita
Endothelin Converting Enzyme-1 Gene Expression in the Kidney of Spontaneously Hypertensive Rats
Hypertension, December 1, 1997; 30(6): 1591 - 1597.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online