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Am J Physiol Renal Physiol 260: F210-F215, 1991;
0363-6127/91 $5.00
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AJP - Renal Physiology, Vol 260, Issue 2 210-F215, Copyright © 1991 by American Physiological Society

ARTICLES

Isolated MTAL cells produce an inhibitor of ouabain-sensitive oxygen consumption

L. G. Cantley, R. Fuhro and P. Silva
Department of Medicine, Beth Israel Hospital, Boston, Massachusetts 02215.

Dispersed medullary thick ascending limb (MTAL) cells of the rabbit kidney produce an inhibitor of transport-related oxygen consumption when incubated at 37 degrees C. Appearance of this inhibitor is enhanced by incubation with arachidonic acid. Its appearance can be prevented by either 10(-6) M nordihydroguaiaretic acid or 10(-4) M indomethacin, but not by 10(-6) M indomethacin. These results suggest that the transport inhibitor is an eicosanoid produced by a pathway other than that catalyzed by cyclooxygenase. It inhibits ouabain-sensitive respiration in intact cells treated with amphotericin, suggesting direct inhibition of the Na(+)-K(+)-ATPase.


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[Abstract] [Full Text] [PDF]


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