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Am J Physiol Renal Physiol 261: F808-F814, 1991;
0363-6127/91 $5.00
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AJP - Renal Physiology, Vol 261, Issue 5 808-F814, Copyright © 1991 by American Physiological Society

ARTICLES

Ion channel activities of cultured rat mesangial cells

H. Matsunaga, N. Yamashita, Y. Miyajima, T. Okuda, H. Chang, E. Ogata and K. Kurokawa
Fourth Department of Internal Medicine, University of Tokyo School of Medicine, Japan.

We used the patch-clamp technique to clarify the nature of ion channels in renal mesangial cells in culture. In the cell-attached mode most patches were silent in the absence of agonists. In some patches a 25-pS nonselective channel was observed. This 25-pS cation channel was consistently observed in inside-out patches, and it was activated by intracellular Ca2+. Excised patch experiments also revealed the existence of a 40-pS K+ channel, which was activated by intracellular Ca2+. This 40-pS K+ channel was observed infrequently in the cell-attached mode. The activities of both channels were increased by arginine vasopressin or angiotensin II, resulting from an increase in intracellular Ca2+ concentration.


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