AJP - Renal Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 261: F1033-F1037, 1991;
0363-6127/91 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Lahera, V.
Right arrow Articles by Romero, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lahera, V.
Right arrow Articles by Romero, J. C.

AJP - Renal Physiology, Vol 261, Issue 6 1033-F1037, Copyright © 1991 by American Physiological Society

ARTICLES

Effects of NG-nitro-L-arginine methyl ester on renal function and blood pressure

V. Lahera, M. G. Salom, F. Miranda-Guardiola, S. Moncada and J. C. Romero
Department of Physiology, Mayo School of Medicine, Rochester, Minnesota 55905.

The dose-dependent effects of intravenous infusions of nitric oxide (NO) synthesis inhibitor, NG-nitro-L-arginine methyl ester (L-NAME; 0.1, 1, 10, and 50 micrograms.kg-1.min-1), were studied in anesthetized rats to determine whether the inhibitory actions of L-NAME are manifested primarily in alterations of renal function or whether they are the consequences of the increase in systemic blood pressure. Mean arterial pressure (MAP) was not altered by the intravenous L-NAME infusions of 0.1 and 1.0 microgram.kg-1.min-1. However, 0.1 microgram.kg-1.min-1 L-NAME induced a 30% decrease in urine flow rate (UV). The administration of 1.0 microgram.kg-1.min-1 L-NAME, in addition to decreasing UV, also decreased urinary sodium excretion (UNaV) and renal plasma flow (RPF). The intravenous L-NAME infusions of 10.0 and 50.0 microgram.kg-1.min-1 intravenous L-NAME infusions of 10.0 and 50.0 microgram.kg-1.min-1 produced significant increases in MAP that reversed the initial fall in UV and UNaV, despite decreasing RPF and glomerular filtration rate (GFR). The administration of L-arginine alone (10 micrograms.kg-1.min-1) did not modify any of the parameters measured, but it effectively prevented all the hemodynamic and renal changes induced by the infusion of 50 micrograms.kg-1.min-1 L-NAME. These results suggest that the decrease in nitric oxide production induced by the intravenous infusion of L-NAME affects renal excretion of sodium and water in the absence of any significant change in blood pressure. At larger doses, L-NAME also produces hypertension that overrides the initial antinatriuretic effect.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
Z. Abassi, B. Bishara, T. Karram, S. Khatib, J. Winaver, and A. Hoffman
Adverse effects of pneumoperitoneum on renal function: involvement of the endothelin and nitric oxide systems
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2008; 294(3): R842 - R850.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Herrera, P. A. Ortiz, and J. L. Garvin
Regulation of thick ascending limb transport: role of nitric oxide
Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1279 - F1284.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. Yanes, D. Romero, R. Iliescu, V. E. Cucchiarelli, L. A. Fortepiani, F. Santacruz, W. Bell, H. Zhang, and J. F. Reckelhoff
Systemic arterial pressure response to two weeks of Tempol therapy in SHR: involvement of NO, the RAS, and oxidative stress
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2005; 288(4): R903 - R908.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Varela, M. Herrera, and J. L. Garvin
Inhibition of Na-K-ATPase in thick ascending limbs by NO depends on O2- and is diminished by a high-salt diet
Am J Physiol Renal Physiol, August 1, 2004; 287(2): F224 - F230.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Graebe, L. Brond, S. Christensen, S. Nielsen, N. V. Olsen, and T. E. N. Jonassen
Chronic nitric oxide synthase inhibition exacerbates renal dysfunction in cirrhotic rats
Am J Physiol Renal Physiol, February 1, 2004; 286(2): F288 - F297.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. F. Reckelhoff and J. C. Romero
Role of oxidative stress in angiotensin-induced hypertension
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2003; 284(4): R893 - R912.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
R. Lopez, M. T. Llinas, F. Roig, and F. J. Salazar
Role of nitric oxide and cyclooxygenase-2 in regulating the renal hemodynamic response to norepinephrine
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R488 - R493.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
P. A. Ortiz and J. L. Garvin
Role of nitric oxide in the regulation of nephron transport
Am J Physiol Renal Physiol, May 1, 2002; 282(5): F777 - F784.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. L. Andersen, N. C. F. Sandgaard, and P. Bie
Volume expansion during acute angiotensin II receptor (AT1) blockade and NOS inhibition in conscious dogs
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R1140 - R1148.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. L. Andersen, N. C. F. Sandgaard, and P. Bie
Volume expansion during NOS substrate donation with L-arginine: regulatory offsetting of renal response?
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R1149 - R1155.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Liang, T. J. Berndt, and F. G. Knox
Mechanism underlying diuretic effect of L-NAME at a subpressor dose
Am J Physiol Renal Physiol, September 1, 2001; 281(3): F414 - F419.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
X.-H. Jin, H. M. Siragy, and R. M. Carey
Renal Interstitial cGMP Mediates Natriuresis by Direct Tubule Mechanism
Hypertension, September 1, 2001; 38(3): 309 - 316.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
S. Lacchini, E. L. Ferlin, R. S. Moraes, J. P. Ribeiro, and M. C. Irigoyen
Contribution of Nitric Oxide to Arterial Pressure and Heart Rate Variability in Rats Submitted to High-Sodium Intake
Hypertension, September 1, 2001; 38(3): 326 - 331.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. V. Peterson, C. Emmeluth, and P. Bie
Renal effects of nitric oxide synthase inhibition in conscious water-loaded dogs
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2001; 281(2): R584 - R590.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
P. A. Ortiz and J. L. Garvin
NO Inhibits NaCl Absorption by Rat Thick Ascending Limb Through Activation of cGMP-Stimulated Phosphodiesterase
Hypertension, February 1, 2001; 37(2): 467 - 471.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Cases, J. Haas, J. C. Burnett, and J. C. Romero
Hemodynamic and renal effects of acute and progressive nitric oxide synthesis inhibition in anesthetized dogs
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2001; 280(1): R143 - R148.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
L.-T. DIJKHORST-OEI, P. BOER, T. J. RABELINK, and H. A. KOOMANS
Nitric Oxide Synthesis Inhibition Does Not Impair Water Immersion-Induced Renal Vasodilation in Humans
J. Am. Soc. Nephrol., July 1, 2000; 11(7): 1293 - 1302.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Liang and F. G. Knox
Production and functional roles of nitric oxide in the proximal tubule
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2000; 278(5): R1117 - R1124.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Hoffman, Z. A. Abassi, S. Brodsky, R. Ramadan, and J. Winaver
Mechanisms of Big Endothelin-1-Induced Diuresis and Natriuresis : Role of ETB Receptors
Hypertension, March 1, 2000; 35(3): 732 - 739.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. M. Stulak, L. A. Juncos, J. A. Haas, and J. C. Romero
Systemic hemodynamics and renal function in hemorrhaged dogs resuscitated with cross-linked hemoglobin
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2000; 278(1): R28 - R33.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
K. D. A. L. d'Avila, G. Gadonski, J. Fang, P. Dall'Ago, V. L. Albuquerque, L. R. d. A. Peixoto, T. G. Fernandes, and M. C. Irigoyen
Exercise Reverses Peripheral Insulin Resistance in Trained L-NAME-Hypertensive Rats
Hypertension, October 1, 1999; 34(4): 768 - 772.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. L. Garvin and N. J. Hong
Nitric oxide inhibits sodium/hydrogen exchange activity in the thick ascending limb
Am J Physiol Renal Physiol, September 1, 1999; 277(3): F377 - F382.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. M. Valdivielso, F. Perez-Barriocanal, J. Garcia-Estan, and J. M. Lopez-Novoa
Role of nitric oxide in the early renal hemodynamic response after unilateral nephrectomy
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1718 - R1723.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Broere, A. H. Van Den Meiracker, F. Boomsma, F. H. M. Derkx, A. J. Man In'T Veld, and M. A. D. H. Schalekamp
Human renal and systemic hemodynamic, natriuretic, and neurohumoral responses to different doses of L-NAME
Am J Physiol Renal Physiol, December 1, 1998; 275(6): F870 - F877.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. Azam, G. Gupta, W. Chen, S. Wellington, D. Warburton, and R. S. Danziger
Genetic Mapping of Soluble Guanylyl Cyclase Genes : Implications for Linkage to Blood Pressure in the Dahl Rat
Hypertension, July 1, 1998; 32(1): 149 - 154.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
S. K. Laycock, T. Vogel, P. R. Forfia, J. Tuzman, X. Xu, M. Ochoa, C. I. Thompson, A. Nasjletti, and T. H. Hintze
Role of Nitric Oxide in the Control of Renal Oxygen Consumption and the Regulation of Chemical Work in the Kidney
Circ. Res., June 29, 1998; 82(12): 1263 - 1271.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Y. Chin, C.-T. Wang, D. S. A. Majid, and L. G. Navar
Renoprotective effects of nitric oxide in angiotensin II-induced hypertension in the rat
Am J Physiol Renal Physiol, May 1, 1998; 274(5): F876 - F882.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
J. N. Bech, C. B. Nielsen, P. Ivarsen, K. T. Jensen, and E. B. Pedersen
Dietary sodium affects systemic and renal hemodynamic response to NO inhibition in healthy humans
Am J Physiol Renal Physiol, May 1, 1998; 274(5): F914 - F923.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
E. Eitle, S. Hiranyachattada, H. Wang, and P. J. Harris
Inhibition of proximal tubular fluid absorption by nitric oxide and atrial natriuretic peptide in rat kidney
Am J Physiol Cell Physiol, April 1, 1998; 274(4): C1075 - C1080.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. D. Krier and J. C. Romero
Systemic inhibition of nitric oxide and prostaglandins in volume-induced natriuresis and hypertension
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1998; 274(1): R175 - R180.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
J. G. Filep
Endogenous Endothelin Modulates Blood Pressure, Plasma Volume, and Albumin Escape After Systemic Nitric Oxide Blockade
Hypertension, July 1, 1997; 30(1): 22 - 28.
[Abstract] [Full Text]

Home page
 HypertensionHome page
L.-T. Dijkhorst-Oei, T. J. Rabelink, P. Boer, and H. A. Koomans
Nifedipine Attenuates Systemic and Renal Vasoconstriction During Nitric Oxide Inhibition in Humans
Hypertension, May 1, 1997; 29(5): 1192 - 1198.
[Abstract] [Full Text]

Home page
 HypertensionHome page
E. S.G. Stroes, T. F. Luscher, F. G. de Groot, H. A. Koomans, and T. J. Rabelink
Cyclosporin A Increases Nitric Oxide Activity In Vivo
Hypertension, February 1, 1997; 29(2): 570 - 575.
[Abstract] [Full Text]

Home page
 HypertensionHome page
Y. Erlich and T. Rosenthal
Contribution of Nitric Oxide to the Beneficial Effects of Enalapril in the Fructose-Induced Hyperinsulinemic Rat
Hypertension, November 1, 1996; 28(5): 754 - 757.
[Abstract] [Full Text]

Home page
 HypertensionHome page
D. Rees, D. Ben-Ishay, and S. Moncada
Nitric Oxide and the Regulation of Blood Pressure in the Hypertension-Prone and Hypertension-Resistant Sabra Rat
Hypertension, September 1, 1996; 28(3): 367 - 371.
[Abstract] [Full Text]

Home page
 CirculationHome page
R. A. Cohen and P. M. Vanhoutte
Endothelium-Dependent Hyperpolarization : Beyond Nitric Oxide and Cyclic GMP
Circulation, December 1, 1995; 92(11): 3337 - 3349.
[Full Text]

Home page
 HypertensionHome page
Y. Ikeda, K. Saito, J.-I. Kim, and M. Yokoyama
Nitric Oxide Synthase Isoform Activities in Kidney of Dahl Salt-Sensitive Rats
Hypertension, December 1, 1995; 26(6): 1030 - 1034.
[Abstract] [Full Text]

Home page
 HypertensionHome page
V. Cachofeiro, R. Maeso, E. Rodrigo, J. Navarro, L. M. Ruilope, and V. Lahera
Nitric Oxide and Prostaglandins in the Prolonged Effects of Losartan and Ramipril in Hypertension
Hypertension, August 1, 1995; 26(2): 236 - 243.
[Abstract] [Full Text]

Home page
 HypertensionHome page
T. L. Krukoff, F. Gehlen, D. Ganten, and J. Wagner
Gene Expression of Brain Nitric Oxide Synthase and Soluble Guanylyl Cyclase in Hypothalamus and Medulla of Two-Kidney, One Clip Hypertensive Rats
Hypertension, July 1, 1995; 26(1): 171 - 176.
[Abstract] [Full Text]

Home page
 HypertensionHome page
T. Okamura, K. Yoshida, and N. Toda
Nitroxidergic Innervation in Dog and Monkey Renal Arteries
Hypertension, May 1, 1995; 25(5): 1090 - 1095.
[Abstract] [Full Text]

Home page
 HypertensionHome page
C. Qiu, K. Engels, L. Samsell, and C. Baylis
Renal Effects of Acute Amino Acid Infusion in Hypertension Induced by Chronic Nitric Oxide Blockade
Hypertension, January 1, 1995; 25(1): 61 - 66.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online