AJP - Renal Add DOIs to your references at manuscript stage!
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 262: F718-F722, 1992;
0363-6127/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Salom, M. G.
Right arrow Articles by Romero, J. C.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Salom, M. G.
Right arrow Articles by Romero, J. C.

AJP - Renal Physiology, Vol 262, Issue 5 718-F722, Copyright © 1992 by American Physiological Society

ARTICLES

Blockade of pressure natriuresis induced by inhibition of renal synthesis of nitric oxide in dogs

M. G. Salom, V. Lahera, F. Miranda-Guardiola and J. C. Romero
Department of Physiology and Biophysics, Mayo Clinic, Rochester, Minnesota 55905.

To evaluate the participation of nitric oxide (NO) on pressure-induced natriuresis in pentobarbital-anesthetized dogs, renal perfusion pressure (RPP) was increased twice from 100 to 150 mmHg before and during the intrarenal administration of an NO-synthesis inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), while determining changes in glomerular filtration rate (GFR), renal blood flow (RBF), and urine sodium and water excretion. Before the inhibition of NO, the increase in RPP induced diuresis (5-fold) and natriuresis (4.2-fold) with no change in RBF or GFR. However, the intrarenal infusion of L-NAME (1 microgram.kg-1.min-1) blunted the diuretic and natriuretic responses without altering RBF or GFR. The infusion of the NO synthesis precursor L-arginine prevented the inhibitory effect that L-NAME exerted on the diuretic and natriuretic responses to the increase in RPP. These results indicate that the increase in RPP stimulates NO synthesis and suggest that NO might play an important role in the control of sodium and water excretion during acute changes in RPP.


This article has been cited by other articles:


Home page
 HypertensionHome page
M. P. Schneider, Y. Ge, D. M. Pollock, J. S. Pollock, and D. E. Kohan
Collecting Duct-Derived Endothelin Regulates Arterial Pressure and Na Excretion via Nitric Oxide
Hypertension, June 1, 2008; 51(6): 1605 - 1610.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Varela, M. Herrera, and J. L. Garvin
Inhibition of Na-K-ATPase in thick ascending limbs by NO depends on O2- and is diminished by a high-salt diet
Am J Physiol Renal Physiol, August 1, 2004; 287(2): F224 - F230.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
X.-H. Jin, H. E. McGrath, J. J. Gildea, H. M. Siragy, R. A. Felder, and R. M. Carey
Renal Interstitial Guanosine Cyclic 3', 5'-Monophosphate Mediates Pressure-Natriuresis Via Protein Kinase G
Hypertension, May 1, 2004; 43(5): 1133 - 1139.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
T. V. Peterson, C. Emmeluth, and P. Bie
Renal effects of nitric oxide synthase inhibition in conscious water-loaded dogs
Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2001; 281(2): R584 - R590.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. Govers and T. J. Rabelink
Cellular regulation of endothelial nitric oxide synthase
Am J Physiol Renal Physiol, February 1, 2001; 280(2): F193 - F206.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Cases, J. Haas, J. C. Burnett, and J. C. Romero
Hemodynamic and renal effects of acute and progressive nitric oxide synthesis inhibition in anesthetized dogs
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2001; 280(1): R143 - R148.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Hoffman, Z. A. Abassi, S. Brodsky, R. Ramadan, and J. Winaver
Mechanisms of Big Endothelin-1-Induced Diuresis and Natriuresis : Role of ETB Receptors
Hypertension, March 1, 2000; 35(3): 732 - 739.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
M. McIntyre, D. F. Bohr, and A. F. Dominiczak
Endothelial Function in Hypertension : The Role of Superoxide Anion
Hypertension, October 1, 1999; 34(4): 539 - 545.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. Braam
Renal endothelial and macula densa NOS: integrated response to changes in extracellular fluid volume
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1551 - R1561.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
F. Wu, F. Park, A. W. Cowley Jr., and D. L. Mattson
Quantification of nitric oxide synthase activity in microdissected segments of the rat kidney
Am J Physiol Renal Physiol, June 1, 1999; 276(6): F874 - F881.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
X.-Z. Zhang and C. Baylis
Endothelin mediates renal vascular memory of a transient rise in perfusion pressure due to NOS inhibition
Am J Physiol Renal Physiol, April 1, 1999; 276(4): F629 - F634.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
L. A. FORTEPIANI, E. RODRIGO, M. C. ORTÍZ, V. CACHOFEIRO, N. M. ATUCHA, L. M. RUILOPE, V. LAHERA, and J. GARCÍA-ESTAÑ
Pressure Natriuresis in Nitric Oxide-Deficient Hypertensive Rats: Effect of Antihypertensive Treatments
J. Am. Soc. Nephrol., January 1, 1999; 10(1): 21 - 27.
[Abstract] [Full Text]

Home page
 J. Pharmacol. Exp. Ther.Home page
Y. Matsumura, M. Nishiura, S. Deguchi, N. Hashimoto, T. Ogawa, and R. Seo
Protective Effect of FK409, a Spontaneous Nitric Oxide Releaser, on Ischemic Acute Renal Failure in Rats
J. Pharmacol. Exp. Ther., December 1, 1998; 287(3): 1084 - 1091.
[Abstract] [Full Text]

Home page
 HypertensionHome page
R. Zatz and C. Baylis
Chronic Nitric Oxide Inhibition Model Six Years On
Hypertension, December 1, 1998; 32(6): 958 - 964.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
N. Miyata, A. P. Zou, D. L. Mattson, and A. W. Cowley Jr.
Renal medullary interstitial infusion of L-arginine prevents hypertension in Dahl salt-sensitive rats
Am J Physiol Regulatory Integrative Comp Physiol, November 1, 1998; 275(5): R1667 - R1673.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D. S. A. Majid, S. A. Omoro, S. Y. Chin, and L. G. Navar
Intrarenal Nitric Oxide Activity and Pressure Natriuresis in Anesthetized Dogs
Hypertension, August 1, 1998; 32(2): 266 - 272.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
R. F. Husted, J. P. Rapp, and J. B. Stokes
Candidate Genes in the Regulation of Na+ Transport by Inner Medullary Collecting Duct Cells From Dahl Rats
Hypertension, February 1, 1998; 31(2): 608 - 614.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. D. Krier and J. C. Romero
Systemic inhibition of nitric oxide and prostaglandins in volume-induced natriuresis and hypertension
Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1998; 274(1): R175 - R180.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D. S. A. Majid, M. Godfrey, and L. G. Navar
Pressure Natriuresis and Renal Medullary Blood Flow in Dogs
Hypertension, April 1, 1997; 29(4): 1051 - 1057.
[Abstract] [Full Text]

Home page
 HypertensionHome page
D. L. Mattson and T. G. Bellehumeur
Neural Nitric Oxide Synthase in the Renal Medulla and Blood Pressure Regulation
Hypertension, August 1, 1996; 28(2): 297 - 303.
[Abstract] [Full Text]

Home page
 HypertensionHome page
S. S. Yamada, A. L. Sassaki, C. K. Fujihara, D. M. Avancini Costa Malheiros, G. De Nucci, and R. Zatz
Effect of Salt Intake and Inhibitor Dose on Arterial Hypertension and Renal Injury Induced by Chronic Nitric Oxide Blockade
Hypertension, May 1, 1996; 27(5): 1165 - 1172.
[Abstract] [Full Text]

Home page
 HypertensionHome page
M. C. Ortiz, N. M. Atucha, V. Lahera, F. Vargas, T. Quesada, and J. Garcia-Estan
Importance of Nitric Oxide and Prostaglandins in the Control of Rat Renal Papillary Blood Flow
Hypertension, March 1, 1996; 27(3): 377 - 381.
[Abstract] [Full Text]

Home page
 HypertensionHome page
D. L. Mattson and D. J. Higgins
Influence of Dietary Sodium Intake on Renal Medullary Nitric Oxide Synthase
Hypertension, March 1, 1996; 27(3): 688 - 692.
[Abstract] [Full Text]

Home page
 HypertensionHome page
Y. Ikeda, K. Saito, J.-I. Kim, and M. Yokoyama
Nitric Oxide Synthase Isoform Activities in Kidney of Dahl Salt-Sensitive Rats
Hypertension, December 1, 1995; 26(6): 1030 - 1034.
[Abstract] [Full Text]

Home page
 HypertensionHome page
A. W. Cowley Jr, D. L. Mattson, S. Lu, and R. J. Roman
The Renal Medulla and Hypertension
Hypertension, April 1, 1995; 25(4): 663 - 673.
[Abstract] [Full Text]

Home page
 HypertensionHome page
C. Qiu, K. Engels, L. Samsell, and C. Baylis
Renal Effects of Acute Amino Acid Infusion in Hypertension Induced by Chronic Nitric Oxide Blockade
Hypertension, January 1, 1995; 25(1): 61 - 66.
[Abstract] [Full Text]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online