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Am J Physiol Renal Physiol 262: F837-F842, 1992;
0363-6127/92 $5.00
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AJP - Renal Physiology, Vol 262, Issue 5 837-F842, Copyright © 1992 by American Physiological Society

ARTICLES

Mercury weakens membrane anchoring of Na-K-ATPase

E. Imesch, M. Moosmayer and B. M. Anner
Department of Pharmacology, Geneva University Medical Center, Switzerland.

The presence of circulating inhibitors able to decrease the renal Na-K-adenosinetriphosphatase (ATPase) activity (natriuretic hormones) was postulated some 30 years ago. In the present work, the natriuretic inhibitor HgCl2 was selected as a model compound for the structural characterization of a possible natriuretic pathway for Na-K-ATPase modification. The structural effects of Na-K-ATPase inhibition by HgCl2 were assessed by trypsinolysis of the blocked enzyme in comparison with untreated preparations. The results show that inactivation of Na-K-ATPase by HgCl2 leads to the release of the alpha-subunit from the membrane preferentially in the E2 conformation but also in the E1 conformation. Apparently, HgCl2 weakens the membrane anchoring of the alpha-subunit, presumably by loosening the alpha-beta-subunit interaction. By this mechanism, the sensitivity of the Na-K-ATPase to extracellular drugs, hormones, and antibodies, as well as to intracellular proteases and other regulatory factors, could be altered.


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