AJP - Renal AJP: Regulatory, Integrative and Comparative Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 262: F1068-F1075, 1992;
0363-6127/92 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jensen, L. L.
Right arrow Articles by Wright, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jensen, L. L.
Right arrow Articles by Wright, J. W.

AJP - Renal Physiology, Vol 262, Issue 6 1068-F1075, Copyright © 1992 by American Physiological Society

ARTICLES

Role of paraventricular nucleus in control of blood pressure and drinking in rats

L. L. Jensen, J. W. Harding and J. W. Wright
Department of Psychology, Washington State University, Pullman 99164.

The present investigation examined the abilities of angiotensin (ANG) II and III to produce increases in blood pressure and drinking when microinfused into the paraventricular nucleus (PVN) of the hypothalamus of the Sprague-Dawley rat. Dose-dependent elevations in systemic blood pressure and heart rate were measured to both ANG II and III in the anesthetized rat, with ANG II more potent than ANG III at the two highest doses examined. Pretreatment with the specific ANG receptor antagonist [Sar1,Thr8]ANG II (sarthran), blocked subsequent ANG II- and III-induced elevations in blood pressure, suggesting that these responses were dependent on the activation of ANG receptors. A similar analysis in awake rats yielded nearly equivalent results. A final experiment demonstrated that microinfusions of ANG II and III into the PVN produced drinking in a dose-dependent manner, with greater consumption to ANG II than ANG III. Again, sarthran was found to block the dipsogenic response. Histological examination revealed that the location of the injection site was linked to the character of the ANG-dependent response. These data suggest that the PVN may play a critical role in mediating central ANG effects on body water homeostasis and blood pressure regulation. Furthermore, it appears that subnuclei of the PVN may participate differentially in ANG-mediated actions.


This article has been cited by other articles:


Home page
 J. Neurophysiol.Home page
Q. Chen and H.-L. Pan
Signaling Mechanisms of Angiotensin II-Induced Attenuation of GABAergic Input to Hypothalamic Presympathetic Neurons
J Neurophysiol, May 1, 2007; 97(5): 3279 - 3287.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
H. E. De Wardener
The Hypothalamus and Hypertension
Physiol Rev, October 1, 2001; 81(4): 1599 - 1658.
[Abstract] [Full Text] [PDF]

Home page
 Exp. Biol. Med.Home page
A. V. Ferguson, D. L.S. Washburn, and K. J. Latchford
Hormonal and Neurotransmitter Roles for Angiotensin in the Regulation of Central Autonomic Function
Experimental Biology and Medicine, February 1, 2001; 226(2): 85 - 96.
[Abstract] [Full Text]

Home page
 Circ. Res.Home page
R. L. Davisson, G. Yang, T. G. Beltz, M. D. Cassell, A. K. Johnson, and C. D. Sigmund
The Brain Renin-Angiotensin System Contributes to the Hypertension in Mice Containing Both the Human Renin and Human Angiotensinogen Transgenes
Circ. Res., November 16, 1998; 83(10): 1047 - 1058.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
J. T. FITZSIMONS
Angiotensin, Thirst, and Sodium Appetite
Physiol Rev, July 1, 1998; 78(3): 583 - 686.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online