AJP - Renal Physiology, Vol 262, Issue 6 927-F931, Copyright © 1992 by American Physiological Society

ARTICLES

Corticosterone 6 beta-hydroxylation correlates with blood pressure in spontaneously hypertensive rats

C. O. Watlington, L. B. Kramer, E. G. Schuetz, J. Zilai, W. M. Grogan, P. Guzelian, F. Gizek and A. C. Schoolwerth
Division of Endocrinology and Metabolism, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298-0145.

Evidence for increased glucocorticoid 6 beta-hydroxylation (enhanced family 3A cytochrome P-450 activity) is found in certain reversible forms of human hypertension. This association was investigated in the spontaneously hypertensive rat (SHR). The proportion of injected [3H]corticosterone excreted in urine as 6 beta-[3H]OH-corticosterone was four- to fivefold higher in SHR than in control Wistar-Kyoto rats, before and after development of overt hypertension. Both hypertension and 6 beta-hydroxylation were inhibited by troleandomycin (a selective inhibitor of family 3A cytochromes P-450), consistent with a role for increased steroid 6 beta-hydroxylation in the genesis of hypertension in the SHR.

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