AJP - Renal Physiology, Vol 262, Issue 6 932-F938, Copyright © 1992 by American Physiological Society

ARTICLES

Intrarenal DA2 dopamine receptor stimulation in the conscious dog

H. M. Siragy, R. A. Felder, M. J. Peach and R. M. Carey
Department of Medicine, University of Virginia, School of Medicine, Charlottesville 22908.

DA2 dopamine receptors are present in renal blood vessels and glomeruli. Stimulation of DA1 dopamine receptors leads to renal vasodilation, diuresis, and natriuresis, but a functional role for renal DA2 receptors is largely unknown. We investigated the possible role of DA2 receptors in the control of renal function by intrarenal infusion of a highly specific DA2 agonist, LY 171555 (LY), in conscious uninephrectomized dogs (n = 5) in metabolic balance at sodium intake of 40 meq/day. The infusion of LY at 0.5 pmol.kg-1.min-1 did not change the urinary sodium excretion or renal hemodynamic function. A significant dose-dependent antidiuresis (F = 8.1, P less than 0.0001) and antinatriuresis (F = 93.3, P less than 0.0001) and a decrease in filtration fraction (F = 2.3, P less than 0.02) occurred as the LY dose was increased from 1.0 to 10.0 pmol.kg-1.min-1. There were no changes in systemic plasma renin activity, plasma aldosterone concentration, or mean arterial pressure during intrarenal LY administration. These data suggest that intrarenal DA2 receptor stimulation with LY decreases renal sodium excretion in part by hemodynamic mechanisms. Renal dopamine may act at vascular and/or glomerular DA2 receptors to modulate renal function.

This article has been cited by other articles:

				T. Hussain and M. F. Lokhandwala Renal Dopamine Receptors and Hypertension Experimental Biology and Medicine, February 1, 2003; 228(2): 134 - 142. [Abstract] [Full Text] [PDF]

				G. Luippold, S. Schneider, V. Vallon, H. Osswald, and B. Muhlbauer Postglomerular vasoconstriction induced by dopamine D3 receptor activation in anesthetized rats Am J Physiol Renal Physiol, April 1, 2000; 278(4): F570 - F575. [Abstract] [Full Text] [PDF]

				T. Hussain, R. Abdul-Wahab, D. K. Kotak, and M. F. Lokhandwala Bromocriptine Regulates Angiotensin II Response on Sodium Pump in Proximal Tubules Hypertension, December 1, 1998; 32(6): 1054 - 1059. [Abstract] [Full Text] [PDF]

				D. P. O'Connell, C. J. Vaughan, A. M. Aherne, S. J. Botkin, Z.-Q. Wang, R. A. Felder, and R. M. Carey Expression of the Dopamine D3 Receptor Protein in the Rat Kidney Hypertension, November 1, 1998; 32(5): 886 - 895. [Abstract] [Full Text] [PDF]

				P. A. Jose, L. D. Asico, G. M. Eisner, F. Pocchiari, C. Semeraro, and R. A. Felder Effects of costimulation of dopamine D1- and D2-like receptors on renal function Am J Physiol Regulatory Integrative Comp Physiol, October 1, 1998; 275(4): R986 - R994. [Abstract] [Full Text] [PDF]

				G. Luippold and B. Mühlbauer Dopamine D2 Receptors Mediate Glomerular Hyperfiltration Due To Amino Acids J. Pharmacol. Exp. Ther., September 1, 1998; 286(3): 1248 - 1252. [Abstract] [Full Text]

				R. Ozono, D. P. O'Connell, C. Vaughan, S. J. Botkin, S. F. Walk, R. A. Felder, and R. M. Carey Expression of the Subtype 1A Dopamine Receptor in the Rat Heart Hypertension, March 1, 1996; 27(3): 693 - 703. [Abstract] [Full Text]