AJP - Renal Physiology, Vol 262, Issue 6 965-F971, Copyright © 1992 by American Physiological Society
Sequential changes in renal oxygen consumption and sodium transport during hyperdynamic sepsis in sheep
A. Weber, I. M. Schwieger, O. Poinsot, M. Klohn, D. M. Gaumann and D. R. Morel
Department of Surgery and Anesthesiology, University Medical Center, Geneva, Switzerland.
The sequence of changes in systemic and renal oxygen delivery (QO2) and
consumption (VO2) and renal function in an ovine model of progressive
hyperdynamic sepsis was investigated. Nine chronically instrumented awake
sheep were given a continuous intravenous Escherichia coli endotoxin
infusion (20 ng.kg-1.min-1) for 3 days. After 8 h of the infusion, systemic
arterial blood pressure and vascular resistance stayed decreased by 30% (P
less than 0.001). Systemic QO2 progressively increased to a maximum of 157%
of baseline values at 24 h and was associated with a decreased O2
extraction ratio from 33 +/- 2 (SE) to 23 +/- 2% (P less than 0.05),
resulting in an unchanged systemic VO2. Renal blood flow and renal QO2
decreased by 40% during the first 12 h, returning to and staying at
baseline values after 24 h. Renal VO2 decreased significantly by 35% at 12
h and then partially recovered to baseline values. Plasma creatinine
clearance was maximally reduced to 25% of baseline values at 12 h and
thereafter remained significantly (P less than 0.01) below 50% of baseline
values. Both total and fractional sodium excretion fell at 12 h by 95 and
74%, respectively, and remained reduced over time, indicating conserved
tubular function. The ratio of moles of sodium reabsorbed to moles of O2
consumed by the kidney was transiently reduced, from 33.4 +/- 4.1 to 12.4
+/- 3.6 at 12 h (P less than 0.05), indicating a relative increase in
energy expenditure for tubular transport or renal synthetic activities, but
recovered to baseline values after 24 h.(ABSTRACT TRUNCATED AT 250 WORDS)
