| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Renal Physiology, Vol 263, Issue 2 256-F261, Copyright © 1992 by American Physiological Society
ARTICLES |
D. H. Sigmon, O. A. Carretero and W. H. Beierwaltes
Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Michigan 48202.
Endothelium-derived relaxing factor (EDRF), through its inhibitory second messenger guanosine 3',5'-cyclic monophosphate (cGMP), inhibits renin release in vitro. To determine whether EDRF affects renin in vivo, we tested whether EDRF synthesis inhibition could stimulate renin secretion in intact rats. Because EDRF synthesis inhibition increases blood pressure and consequently withdraws sympathetic activity (both renin inhibitory signals), we also studied the effect of L-N omega-nitroarginine methyl ester (L-NAME) when renal perfusion pressure was controlled and during beta-adrenergic blockade. Mean blood pressure (BP), heart rate (HR), and plasma renin activity (PRA) were measured in anesthetized rats before and after EDRF synthesis inhibition by a 10 mg/kg body wt bolus of L-NAME. L-NAME decreased PRA by 67% [from 11.0 +/- 2.7 to 3.7 +/- 0.8 ng angiotensin I (ANG I).ml-1.h-1, n = 12; P less than 0.001], increased BP by 20 +/- 2 mmHg (P less than 0.001), and decreased HR from 332 +/- 8 to 312 +/- 9 beats/min (P less than 0.005). We repeated our experiment in rats instrumented with an intra-aortic balloon catheter to control renal perfusion pressure and pretreated with propranolol to eliminate the beta-adrenergic effect. Under these conditions, L-NAME now increased PRA by 55% (from 6.9 +/- 1.9 to 10.8 +/- 2.6 ng ANG I.ml-1.h-1, n = 12; P less than 0.02), whereas renal perfusion pressure was unchanged (91 +/- 4 vs. 90 +/- 4 mmHg). HR increased slightly from 308 +/- 5 to 315 +/- 3 beats/min (P less than 0.005).(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  A. Paliege, D. Mizel, C. Medina, A. Pasumarthy, Y. G. Huang, S. Bachmann, J. P. Briggs, J. B. Schnermann, and T. Yang Inhibition of nNOS expression in the macula densa by COX-2-derived prostaglandin E2 Am J Physiol Renal Physiol, July 1, 2004; 287(1): F152 - F159. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Castrop, F. Schweda, D. Mizel, Y. Huang, J. Briggs, A. Kurtz, and J. Schnermann Permissive role of nitric oxide in macula densa control of renin secretion Am J Physiol Renal Physiol, May 1, 2004; 286(5): F848 - F857. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Cases, J. Haas, J. C. Burnett, and J. C. Romero Hemodynamic and renal effects of acute and progressive nitric oxide synthesis inhibition in anesthetized dogs Am J Physiol Regulatory Integrative Comp Physiol, January 1, 2001; 280(1): R143 - R148. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kurtz and C. Wagner Role of nitric oxide in the control of renin secretion Am J Physiol Renal Physiol, December 1, 1998; 275(6): F849 - F862. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Broere, A. H. Van Den Meiracker, F. Boomsma, F. H. M. Derkx, A. J. Man In'T Veld, and M. A. D. H. Schalekamp Human renal and systemic hemodynamic, natriuretic, and neurohumoral responses to different doses of L-NAME Am J Physiol Renal Physiol, December 1, 1998; 275(6): F870 - F877. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P. T. Nowicki Effects of sustained flow reduction on postnatal intestinal circulation Am J Physiol Gastrointest Liver Physiol, October 1, 1998; 275(4): G758 - G768. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Kurtz, K.-H. Gotz, M. Hamann, and C. Wagner Stimulation of renin secretion by nitric oxide is mediated by phosphodiesterase 3 PNAS, April 14, 1998; 95(8): 4743 - 4747. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Kurtz, K.-H. Gotz, M. Hamann, M. Kieninger, and C. Wagner Stimulation of renin secretion by NO donors is related to the cAMP pathway Am J Physiol Renal Physiol, April 1, 1998; 274(4): F709 - F717. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Schnermann Juxtaglomerular cell complex in the regulation of renal salt excretion Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1998; 274(2): R263 - R279. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. D. Krier and J. C. Romero Systemic inhibition of nitric oxide and prostaglandins in volume-induced natriuresis and hypertension Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1998; 274(1): R175 - R180. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. G. Shesely, N. Maeda, H.-S. Kim, K. M. Desai, J. H. Krege, V. E. Laubach, P. A. Sherman, W. C. Sessa, and O. Smithies Elevated blood pressures in mice lacking endothelial nitric oxide synthase PNAS, November 12, 1996; 93(23): 13176 - 13181. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Matsuoka, M. Nakata, K. Kohno, Y. Koga, G. Nomura, H. Toshima, and T. Imaizumi Chronic L-Arginine Administration Attenuates Cardiac Hypertrophy in Spontaneously Hypertensive Rats Hypertension, January 1, 1996; 27(1): 14 - 18. [Abstract] [Full Text]
|
|
|
|
|
|
H. Guan, V. Cachofeiro, M. L. Pucci, P. M. Kaminski, M. S. Wolin, and A. Nasjletti Nitric Oxide and the Depressor Response to Angiotensin Blockade in Hypertension Hypertension, January 1, 1996; 27(1): 19 - 24. [Abstract] [Full Text]
|
|
|
|
|
|
W. H. Beierwaltes, D'A. L. Potter, O. A. Carretero, and D. H. Sigmon Nitric Oxide Synthesis Inhibition Blocks Reversal of Two-Kidney, One Clip Renovascular Hypertension After Unclipping Hypertension, February 1, 1995; 25(2): 174 - 179. [Abstract] [Full Text]
|
|
|
|
|
|
W. H. Beierwaltes, D'A. L. Potter, and E. G. Shesely Renal baroreceptor-stimulated renin in the eNOS knockout mouse Am J Physiol Renal Physiol, January 1, 2002; 282(1): F59 - F64. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
