AJP - Renal Physiology, Vol 263, Issue 3 496-F502, Copyright © 1992 by American Physiological Society

ARTICLES

Renal injury in obese Zucker rats: glomerular hemodynamic alterations and effects of enalapril

P. G. Schmitz, M. P. O'Donnell, B. L. Kasiske, S. A. Katz and W. F. Keane
Department of Medicine, Hennepin County Medical Center, Minneapolis, Minnesota 55415.

Angiotensin-converting enzyme inhibitors may ameliorate experimental glomerular injury by either hemodynamic or nonhemodynamic mechanisms. In a long-term study, we examined the effects of 30 wk of enalapril treatment on the development of glomerular disease in obese Zucker rats (OZR). Enalapril significantly (P less than 0.05) lowered blood pressure, fasting serum cholesterol, and urine albumin excretion in OZR throughout the experimental period. At 38 wk of age, enalapril-treated OZR had a sixfold reduction in the percent glomeruli exhibiting focal glomerulosclerosis and a 20-30% reduction in kidney weight and glomerular area. A separate micropuncture study in 22- to 26-wk-old rats revealed that untreated OZR with albuminuria and increased blood pressure had elevated glomerular capillary pressure (Pgc). Enalapril-treated OZR had less albuminuria and lower blood pressure, but Pgc was not reduced. The value of the transcapillary hydraulic pressure difference (delta P) in enalapril-treated OZR was intermediate between values in untreated OZR and lean Zucker rats. Thus enalapril markedly attenuated the development of glomerular injury in OZR. The salutary effects of enalapril may have involved a reduction in delta P coupled to a nonhemodynamic action, possibly restriction of glomerular growth or lowering of serum cholesterol.

This article has been cited by other articles:

				J. Trujillo, C. Cruz, A. Tovar, V. Vaidya, E. Zambrano, J. V. Bonventre, G. Gamba, N. Torres, and N. A. Bobadilla Renoprotective mechanisms of soy protein intake in the obese Zucker rat Am J Physiol Renal Physiol, November 1, 2008; 295(5): F1574 - F1582. [Abstract] [Full Text] [PDF]

				K. A. Griffin, H. Kramer, and A. K. Bidani Adverse renal consequences of obesity Am J Physiol Renal Physiol, April 1, 2008; 294(4): F685 - F696. [Abstract] [Full Text] [PDF]

				J. Trujillo, V. Ramirez, J. Perez, I. Torre-Villalvazo, N. Torres, A. R. Tovar, R. M. Munoz, N. Uribe, G. Gamba, and N. A. Bobadilla Renal protection by a soy diet in obese Zucker rats is associated with restoration of nitric oxide generation Am J Physiol Renal Physiol, January 1, 2005; 288(1): F108 - F116. [Abstract] [Full Text] [PDF]

				D. Villarreal, G. Reams, R. H. Freeman, and A. Taraben Renal effects of leptin in normotensive, hypertensive, and obese rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 1998; 275(6): R2056 - R2060. [Abstract] [Full Text] [PDF]

				P. R. Mertens, V. Espenkott, B. Venjakob, B. Heintz, S. Handt, and H.-G. Sieberth Pressure Oscillation Regulates Human Mesangial Cell Growth and Collagen Synthesis Hypertension, November 1, 1998; 32(5): 945 - 952. [Abstract] [Full Text] [PDF]

				P. H. Lane, L. D. Tyler, and P. G. Schmitz Chronic administration of furosemide augments renal weight and glomerular capillary pressure in normal rats Am J Physiol Renal Physiol, August 1, 1998; 275(2): F230 - F234. [Abstract] [Full Text] [PDF]

				J. C. Clapham and N. C. Turner Effects of the Glucocorticoid II Receptor Antagonist Mifepristone on Hypertension in the Obese Zucker Rat J. Pharmacol. Exp. Ther., September 1, 1997; 282(3): 1503 - 1508. [Abstract] [Full Text]

				C. Baylis, L. Samsell, L. Racusen, and W. Gladfelter Hypothalamic Lesions Induce Obesity and Sex-Dependent Glomerular Damage and Increases in Blood Pressure in Rats Hypertension, April 1, 1996; 27(4): 926 - 932. [Abstract] [Full Text]

				J. Ribstein, G. du Cailar, and A. Mimran Combined Renal Effects of Overweight and Hypertension Hypertension, October 1, 1995; 26(4): 610 - 615. [Abstract] [Full Text]