AJP - Renal Physiology, Vol 263, Issue 3 534-F539, Copyright © 1992 by American Physiological Society

ARTICLES

Effect of cyclooxygenase inhibition on renal blood flow autoregulation in SHR

B. M. Iversen, F. I. Kvam, L. Morkrid, I. Sekse and J. Ofstad
Medical Department A, University of Bergen, Norway.

The effect of acute and chronic indomethacin treatment on renal blood flow (RBF) autoregulation was studied in 10- and 40-wk-old spontaneously hypertensive rats (SHR). RBF autoregulation was substantially reduced in 40-wk-old SHR both during acute and chronic indomethacin treatment, whereas no effect was seen in the young SHR. The pressure range of autoregulation was 169 +/- 9 to 130 +/- 5 mmHg in the untreated 40-wk-old SHR, and 154 +/- 14 to 146 +/- 6 mmHg in indomethacin-treated 40-wk-old SHR (P less than 0.001). Indomethacin treatment had no effect on control RBF, mean arterial pressure, or renal vascular resistance in the 40-wk-old SHR. After removal of the renal nerves, RBF autoregulation during indomethacin treatment was restored in 40-wk-old SHR. The pressure range of RBF autoregulation was 158 +/- 7 to 142 +/- 7 mmHg in sham-operated animals, significantly different from the denervated 40-wk-old SHR, where RBF was autoregulated from 150 +/- 5 to 118 +/- 6 mmHg (P less than 0.01) during indomethacin treatment. The afferent arteriolar diameter (DAA) was studied by the microsphere method in 10-wk-old SHR and in untreated and indomethacin-treated 40-wk-old SHR. DAA was significantly greater in 40-wk-old compared with 10-wk-old SHR (22.1 +/- 0.4 vs. 17.9 +/- 0.5 microns) (P less than 0.01), whereas indomethacin treatment in 40-wk-old SHR did not influence the DAA significantly (21.5 +/- 0.3 microns, P greater than 0.10).(ABSTRACT TRUNCATED AT 250 WORDS)

This article has been cited by other articles:

				F. H. Hansen, O. B. Vagnes, and B. M. Iversen Enhanced response to AVP in the interlobular artery from the spontaneously hypertensive rat Am J Physiol Renal Physiol, May 1, 2005; 288(5): F1023 - F1031. [Abstract] [Full Text] [PDF]

				O. B. Vagnes, F. H. Hansen, R. E. F. Christiansen, C. Gjerstad, and B. M. Iversen Age-dependent regulation of vasopressin V1a receptors in preglomerular vessels from the spontaneously hypertensive rat Am J Physiol Renal Physiol, May 1, 2004; 286(5): F997 - F1003. [Abstract] [Full Text] [PDF]

				C. M. Sorensen, P. P. Leyssac, O. Skott, and N.-H. Holstein-Rathlou NO mediates downregulation of RBF after a prolonged reduction of renal perfusion pressure in SHR Am J Physiol Regulatory Integrative Comp Physiol, August 1, 2003; 285(2): R329 - R338. [Abstract] [Full Text] [PDF]

				A. B. Roald, J. Ofstad, and B. M. Iversen Attenuated buffering of renal perfusion pressure variation in juxtamedullary cortex in SHR Am J Physiol Renal Physiol, March 1, 2002; 282(3): F506 - F511. [Abstract] [Full Text] [PDF]

				O. Vagnes, J. J. Feng, B. M. Iversen, and W. J. Arendshorst Upregulation of V1 receptors in renal resistance vessels of rats developing genetic hypertension Am J Physiol Renal Physiol, June 1, 2000; 278(6): F940 - F948. [Abstract] [Full Text] [PDF]

				E. TURKSTRA, B. BRAAM, and H. A. KOOMANS Impaired Renal Blood Flow Autoregulation in Two-Kidney, One-Clip Hypertensive Rats Is Caused by Enhanced Activity of Nitric Oxide J. Am. Soc. Nephrol., May 1, 2000; 11(5): 847 - 855. [Abstract] [Full Text]

				B. M. Iversen and W. J. Arendshorst Exaggerated Ca2+ signaling in preglomerular arteriolar smooth muscle cells of genetically hypertensive rats Am J Physiol Renal Physiol, February 1, 1999; 276(2): F260 - F270. [Abstract] [Full Text] [PDF]

				B. M. Iversen, F. I. Kvam, K. Matre, and J. Ofstad Resetting of renal blood autoregulation during acute blood pressure reduction in hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, August 1, 1998; 275(2): R343 - R349. [Abstract] [Full Text] [PDF]