| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Renal Physiology, Vol 265, Issue 6 802-F806, Copyright © 1993 by American Physiological Society
ARTICLES |
Y. Agmon, D. Dinour and M. Brezis
Department of Medicine, Hadassah University Hospital, Jerusalem, Israel.
Endogenous adenosine, secreted locally by the kidney during tissue hypoxia, induces heterogeneous renal hemodynamic responses. We investigated the cortical and outer medullary blood flow responses to intrarenal infusions of adenosine and adenosine A1- and A2-receptor agonists in anesthetized rats. These agents were infused into the renal interstitium through chronically implanted capsules, and blood flow was measured by laser-Doppler probes. Short (1 min, 0.05 ml) intrarenal infusions of adenosine (0.5 mumol) lowered cortical blood flow to 27 +/- 10% of baseline (n = 7, P < 0.0005). Medullary blood flow response was biphasic, i.e., a transient decrease in flow to 52 +/- 8% of baseline (n = 17, P < 0.0001) followed by a more-sustained increase in flow to 135 +/- 6% (n = 17, P < 0.0001). N6-cyclopentyladenosine, an adenosine receptor A1 agonist, reduced both cortical and medullary blood flow to 59 +/- 4% (n = 10, P < 0.0001) and 38 +/- 5% (n = 11, P < 0.0001) of baseline, respectively. By contrast, 2-[p- (carboxyethyl)phenethylamino]-5'-N-ethycarboxamidoadenosine (CGS-21680C), an adenosine receptor A2 agonist, increased dramatically the medullary blood flow to 184 +/- 15% of baseline (n = 12, P < 0.0005), without major changes in cortical flow. We conclude that intrarenal adenosine reduces cortical blood flow and predominantly increases medullary flow via A1 and A2 receptors, respectively. These hemodynamic responses could play a role in protection of the outer medulla from hypoxia.
This article has been cited by other articles:
|
|
 |
|
  V. Vallon, B. Muhlbauer, and H. Osswald Adenosine and kidney function. Physiol Rev, July 1, 2006; 86(3): 901 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Neuhofer and F.-X. Beck Survival in Hostile Environments: Strategies of Renal Medullary Cells Physiology, June 1, 2006; 21(3): 171 - 180. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. T. Lee, M. Jan, S. C. Bae, J. D. Joo, F. R. Goubaeva, J. Yang, and M. Kim A1 adenosine receptor knockout mice are protected against acute radiocontrast nephropathy in vivo Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1367 - F1375. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. V. Prasad Functional MRI of the kidney: tools for translational studies of pathophysiology of renal disease Am J Physiol Renal Physiol, May 1, 2006; 290(5): F958 - F974. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. B. Hansen and J. Schnermann Vasoconstrictor and vasodilator effects of adenosine in the kidney Am J Physiol Renal Physiol, October 1, 2003; 285(4): F590 - F599. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
T. L. Pallone, Z. Zhang, and K. Rhinehart Physiology of the renal medullary microcirculation Am J Physiol Renal Physiol, February 1, 2003; 284(2): F253 - F266. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. K. Jackson, C. Zhu, and S. P. Tofovic Expression of adenosine receptors in the preglomerular microcirculation Am J Physiol Renal Physiol, July 1, 2002; 283(1): F41 - F51. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. K. Jackson and R. K. Dubey Role of the extracellular cAMP-adenosine pathway in renal physiology Am J Physiol Renal Physiol, October 1, 2001; 281(4): F597 - F612. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. P. Silldorff and T. L. Pallone Adenosine signaling in outer medullary descending vasa recta Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2001; 280(3): R854 - R861. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. T. LEE and C. W. EMALA Protein Kinase C and Gi/o Proteins Are Involved in Adenosine- and Ischemic Preconditioning--Mediated Renal Protection J. Am. Soc. Nephrol., February 1, 2001; 12(2): 233 - 240. [Abstract] [Full Text]
|
|
|
|
|
|
A. Nishiyama, S. Kimura, H. He, K. Miura, M. Rahman, Y. Fujisawa, T. Fukui, and Y. Abe Renal interstitial adenosine metabolism during ischemia in dogs Am J Physiol Renal Physiol, February 1, 2001; 280(2): F231 - F238. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. C. Hercule and A. O. Oyekan Role of NO and cytochrome P-450-derived eicosanoids in ET-1-induced changes in intrarenal hemodynamics in rats Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2000; 279(6): R2132 - R2141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Nishiyama, A. Miyatake, Y. Aki, T. Fukui, M. Rahman, S. Kimura, and Y. Abe Adenosine A1 Receptor Antagonist KW-3902 Prevents Hypoxia-Induced Renal Vasoconstriction J. Pharmacol. Exp. Ther., December 1, 1999; 291(3): 988 - 993. [Abstract] [Full Text]
|
|
|
|
|
|
M. D. Okusa, J. Linden, T. Macdonald, and L. Huang Selective A2A adenosine receptor activation reduces ischemia-reperfusion injury in rat kidney Am J Physiol Renal Physiol, September 1, 1999; 277(3): F404 - F412. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-P. Zou, K. Nithipatikom, P.-L. Li, and A. W. Cowley Jr. Role of renal medullary adenosine in the control of blood flow and sodium excretion Am J Physiol Regulatory Integrative Comp Physiol, March 1, 1999; 276(3): R790 - R798. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Ralevic and G. Burnstock Receptors for Purines and Pyrimidines Pharmacol. Rev., September 1, 1998; 50(3): 413 - 492. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Abassi, K. Gurbanov, I. Rubinstein, O. S. Better, A. Hoffman, and J. Winaver Regulation of intrarenal blood flow in experimental heart failure: role of endothelin and nitric oxide Am J Physiol Renal Physiol, April 1, 1998; 274(4): F766 - F774. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. Brezis and S. Rosen Hypoxia of the Renal Medulla -- Its Implications for Disease N. Engl. J. Med., March 9, 1995; 332(10): 647 - 655. [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
