AJP - Renal Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 266: F120-F128, 1994;
0363-6127/94 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Von Thun, A. M.
Right arrow Articles by Navar, L. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Von Thun, A. M.
Right arrow Articles by Navar, L. G.

AJP - Renal Physiology, Vol 266, Issue 1 120-F128, Copyright © 1994 by American Physiological Society

ARTICLES

Augmentation of intrarenal angiotensin II levels by chronic angiotensin II infusion

A. M. Von Thun, R. C. Vari, S. S. el-Dahr and L. G. Navar
Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana 70112.

The objective of this study was to investigate the singular role of elevated angiotensin II (ANG II) levels in the development of two-kidney, one-clip (2K1C) Goldblatt hypertension in the rat and specifically in the altered intrarenal ANG II levels that occur in the nonclipped kidney. As a substitute for the clipped kidney, chronic delivery of ANG II (40 ng/min) via an osmotic minipump implanted subcutaneously was used to mimic plasma ANG II levels observed in 2K1C rats during the developmental phase of hypertension. Arterial pressure increased gradually over a period of 14 days, and a pressure profile similar in magnitude and temporal pattern to that of the 2K1C rats was observed. Systemic ANG II was elevated to similar levels in the 2K1C (60 +/- 13 fmol/ml) and ANG II-infused rats (72 +/- 15 fmol/ml) compared with intact two-kidney control animals (31 +/- 6 fmol/ml; P < 0.05) or uninephrectomized rats (13 +/- 1 fmol/ml; P < 0.05). Although renin content was markedly suppressed (80%), intrarenal ANG II content of the contralateral kidneys of the 2K1C groups (86 +/- 12 fmol/g) and the ANG II-infused group (150 +/- 17 fmol/g) was greater than that of the two-kidney control (53 +/- 7 fmol/g; P < 0.05) and uninephrectomized control animals (42 +/- 5 fmol/g; P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 HypertensionHome page
M. C. Prieto-Carrasquero, F. T. Botros, J. Pagan, H. Kobori, D. M. Seth, D. E. Casarini, and L. G. Navar
Collecting Duct Renin Is Upregulated in Both Kidneys of 2-Kidney, 1-Clip Goldblatt Hypertensive Rats
Hypertension, June 1, 2008; 51(6): 1590 - 1596.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Franco, R. Bautista, O. Perez-Mendez, L. Gonzalez, U. Pacheco, L. G. Sanchez-Lozada, J. Santamaria, E. Tapia, R. Monreal, and F. Martinez
Renal interstitial adenosine is increased in angiotensin II-induced hypertensive rats
Am J Physiol Renal Physiol, January 1, 2008; 294(1): F84 - F92.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
X. C. Li, L. G. Navar, Y. Shao, and J. L. Zhuo
Genetic deletion of AT1a receptors attenuates intracellular accumulation of ANG II in the kidney of AT1a receptor-deficient mice
Am J Physiol Renal Physiol, August 1, 2007; 293(2): F586 - F593.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Franco, F. Martinez, Y. Quiroz, O. Galicia, R. Bautista, R. J. Johnson, and B. Rodriguez-Iturbe
Renal angiotensin II concentration and interstitial infiltration of immune cells are correlated with blood pressure levels in salt-sensitive hypertension
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2007; 293(1): R251 - R256.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
X. C. Li, O. A. Carretero, L. G. Navar, and J. L. Zhuo
AT1 receptor-mediated accumulation of extracellular angiotensin II in proximal tubule cells: role of cytoskeleton microtubules and tyrosine phosphatases
Am J Physiol Renal Physiol, August 1, 2006; 291(2): F375 - F383.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
K. D Mitchell, S. J Bagatell, C. S Miller, C. R Mouton, D. M Seth, and J. J Mullins
Genetic Clamping of Renin Gene Expression Induces Hypertension and Elevation of Intrarenal Ang II Levels of Graded Severity in Cyp1a1-Ren2 Transgenic Rats
Journal of Renin-Angiotensin-Aldosterone System, June 1, 2006; 7(2): 74 - 86.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
K. D. Pendergrass, D. B. Averill, C. M. Ferrario, D. I. Diz, and M. C. Chappell
Differential expression of nuclear AT1 receptors and angiotensin II within the kidney of the male congenic mRen2.Lewis rat
Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1497 - F1506.
[Abstract] [Full Text] [PDF]

Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
C. Rugale, M. Cordaillat, A. Mimran, and B. Jover
Prevention and Reversal by Enalapril of Target Organ Damage in Angiotensin II Hypertension
Journal of Renin-Angiotensin-Aldosterone System, September 1, 2005; 6(3): 154 - 160.
[Abstract] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. C. Prieto-Carrasquero, H. Kobori, Y. Ozawa, A. Gutierrez, D. Seth, and L. G. Navar
AT1 receptor-mediated enhancement of collecting duct renin in angiotensin II-dependent hypertensive rats
Am J Physiol Renal Physiol, September 1, 2005; 289(3): F632 - F637.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. M. Bivol, O. B. Vagnes, and B. M. Iversen
The renal vascular response to ANG II injection is reduced in the nonclipped kidney of two-kidney, one-clip hypertension
Am J Physiol Renal Physiol, August 1, 2005; 289(2): F393 - F400.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
F. Schwartz, A. Duka, E. Triantafyllidi, C. Johns, I. Duka, J. Cui, and H. Gavras
Serial analysis of gene expression in mouse kidney following angiotensin II administration
Physiol Genomics, December 16, 2003; 16(1): 90 - 98.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
P. K. K. Leong, Y. Zhang, L. E. Yang, N.-H. Holstein-Rathlou, and A. A. McDonough
Diuretic response to acute hypertension is blunted during angiotensin II clamp
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2002; 283(4): R837 - R842.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
L. G. Navar, L. M. Harrison-Bernard, A. Nishiyama, and H. Kobori
Regulation of Intrarenal Angiotensin II in Hypertension
Hypertension, February 1, 2002; 39(2): 316 - 322.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
J. L. Zhuo, J. D. Imig, T. G. Hammond, S. Orengo, E. Benes, and L. G. Navar
Ang II Accumulation in Rat Renal Endosomes During Ang II-Induced Hypertension: Role of AT1 Receptor
Hypertension, January 1, 2002; 39(1): 116 - 121.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
Y. Huang and D. H. Wang
Role of renin-angiotensin-aldosterone system in salt-sensitive hypertension induced by sensory denervation
Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H2143 - H2149.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. Kobori, L. M. Harrison-Bernard, and L. G. Navar
Enhancement of Angiotensinogen Expression in Angiotensin II-Dependent Hypertension
Hypertension, May 1, 2001; 37(5): 1329 - 1335.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
H. KOBORI, L. M. HARRISON-BERNARD, and L. G. NAVAR
Expression of Angiotensinogen mRNA and Protein in Angiotensin II-Dependent Hypertension
J. Am. Soc. Nephrol., March 1, 2001; 12(3): 431 - 439.
[Abstract] [Full Text]

Home page
 Journal of Renin-Angiotensin-Aldosterone SystemHome page
L G. Navar, K. D Mitchell, L. M Harrison-Bernard, H. Kobori, and A. Nishiyama
Review: Intrarenal angiotensin II levels in normal and hypertensive states
Journal of Renin-Angiotensin-Aldosterone System, March 1, 2001; 2(1_suppl): S176 - S184.
[PDF]

Home page
 HypertensionHome page
A. Nishiyama, T. Fukui, Y. Fujisawa, M. Rahman, R.-X. Tian, S. Kimura, and Y. Abe
Systemic and Regional Hemodynamic Responses to Tempol in Angiotensin II-Infused Hypertensive Rats
Hypertension, January 1, 2001; 37(1): 77 - 83.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C.-T. Wang, S. Y. Chin, and L. G. Navar
Impairment of pressure-natriuresis and renal autoregulation in ANG II-infused hypertensive rats
Am J Physiol Renal Physiol, August 1, 2000; 279(2): F319 - F325.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
E. Mervaala, D. N. Muller, F. Schmidt, J.-K. Park, V. Gross, M. Bader, V. Breu, D. Ganten, H. Haller, and F. C. Luft
Blood Pressure-Independent Effects in Rats With Human Renin and Angiotensinogen Genes
Hypertension, February 1, 2000; 35(2): 587 - 594.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Y. Chin, K. N. Pandey, S.-J. Shi, H. Kobori, C. Moreno, and L. G. Navar
Increased activity and expression of Ca2+-dependent NOS in renal cortex of ANG II-infused hypertensive rats
Am J Physiol Renal Physiol, November 1, 1999; 277(5): F797 - F804.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
L. Song and D. P. Healy
Kidney Aminopeptidase A and Hypertension, Part II : Effects of Angiotensin II
Hypertension, February 1, 1999; 33(2): 746 - 752.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
L. Cervenka, C.-T. Wang, K. D. Mitchell, and L. G. Navar
Proximal Tubular Angiotensin II Levels and Renal Functional Responses to AT1 Receptor Blockade in Nonclipped Kidneys of Goldblatt Hypertensive Rats
Hypertension, January 1, 1999; 33(1): 102 - 107.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
L. M. Harrison-Bernard, S. S. El-Dahr, D. F. O'Leary, and L. G. Navar
Regulation of Angiotensin II Type 1 Receptor mRNA and Protein in Angiotensin II–Induced Hypertension
Hypertension, January 1, 1999; 33(1): 340 - 346.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Ichihara, J. D. Imig, and L. G. Navar
Neuronal Nitric Oxide Synthase-Dependent Afferent Arteriolar Function in Angiotensin II-Induced Hypertension
Hypertension, January 1, 1999; 33(1): 462 - 466.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Ichihara, J. D. Imig, E. W. Inscho, and L. G. Navar
Interactive Nitric Oxide–Angiotensin II Influences on Renal Microcirculation in Angiotensin II–Induced Hypertension
Hypertension, June 1, 1998; 31(6): 1255 - 1260.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. Y. Chin, C.-T. Wang, D. S. A. Majid, and L. G. Navar
Renoprotective effects of nitric oxide in angiotensin II-induced hypertension in the rat
Am J Physiol Renal Physiol, May 1, 1998; 274(5): F876 - F882.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
D. R. Allan, K. Y. Hui, C. Coletti, and N. K. Hollenberg
Renin vs. Angiotensin-Converting Enzyme Inhibition in the Rat: Consequences for Plasma and Renal Tissue Angiotensin
J. Pharmacol. Exp. Ther., November 1, 1997; 283(2): 661 - 665.
[Abstract] [Full Text]

Home page
 HypertensionHome page
L.-X. Zou, J. D. Imig, A. M. Von Thun, A. Hymel, H. Ono, and L. G. Navar
Receptor-Mediated Intrarenal Angiotensin II Augmentation in Angiotensin II–Infused Rats
Hypertension, October 1, 1996; 28(4): 669 - 677.
[Abstract] [Full Text]

Home page
 HypertensionHome page
L.-X. Zou, A. Hymel, J. D. Imig, and L. G. Navar
Renal Accumulation of Circulating Angiotensin II in Angiotensin II–Infused Rats
Hypertension, March 1, 1996; 27(3): 658 - 662.
[Abstract] [Full Text]

Home page
 HypertensionHome page
N. K. Hollenberg and N. D. L. Fisher
Renal Circulation and Blockade of the Renin-Angiotensin System : Is Angiotensin-Converting Enzyme Inhibition the Last Word?
Hypertension, October 1, 1995; 26(4): 602 - 609.
[Abstract] [Full Text]

Home page
 HypertensionHome page
M. Mai, K. F. Hilgers, J. Wagner, J. F. E. Mann, and H. Geiger
Expression of Angiotensin-Converting Enzyme in Renovascular Hypertensive Rat Kidney
Hypertension, April 1, 1995; 25(4): 674 - 678.
[Abstract] [Full Text]

Home page
 HypertensionHome page
M. G. Melaragno and G. D. Fink
Enhanced Slow Pressor Effect of Angiotensin II in Two-Kidney, One Clip Rats
Hypertension, February 1, 1995; 25(2): 288 - 293.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. M. Harrison-Bernard, J. Zhuo, H. Kobori, M. Ohishi, and L. G. Navar
Intrarenal AT1 receptor and ACE binding in ANG II-induced hypertensive rats
Am J Physiol Renal Physiol, January 1, 2002; 282(1): F19 - F25.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online