| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Renal Physiology, Vol 268, Issue 5 821-F828, Copyright © 1995 by American Physiological Society
ARTICLES |
K. D. Mitchell and J. J. Mullins
Department of Physiology, Tulane University School of Medicine, New Orleans, Louisiana 70112, USA.
The present study was performed to determine the angiotensin II (ANG II) dependence of stop-flow pressure (SFP) tubuloglomerular feedback responses in hypertensive transgenic rats [strain name: TGR(mRen2)27] harboring the mouse ren-2 renin gene. SFP feedback responses to increases in late proximal perfusion rate were assessed in pentobarbital-anesthetized male ren-2 transgenic rats during control conditions and after administration of the AT1 receptor antagonist, L-158,809 (1 mg/kg iv). During control conditions, increases in late proximal perfusion rate elicited flow-dependent decreases in SFP. The magnitude of the maximal SFP feedback response to a late proximal perfusion rate of 40 nl/min averaged 16.1 +/- 1.4 mmHg (n = 7), a value higher than that normally observed in normotensive rats. Administration of L-158,809 decreased mean arterial blood pressure (174 +/- 6 vs. 117 +/- mmHg, P < 0.01, n = 10) and attenuated the magnitude of the maximal SFP feedback response by 84 +/- 4% (16.1 +/- 1.4 vs. 2.6 +/- 0.5 mmHg, P < 0.01, n = 7). In contrast, mechanical reduction of renal arterial pressure from 179 +/- 5 to 113 +/- 1 mmHg (P < 0.01, n = 7) attenuated the magnitude of the maximal SFP feedback response by only 43 +/- 5% (14.4 +/- 1.9 vs. 7.9 +/- 0.7 mmHg, P < 0.01, n = 7), indicating that approximately one-half of the attenuation of SFP feed-back responses elicited by AT1 receptor blockade was due to removal of the stimulatory effect of ANG II on the sensitivity of the tubuloglomerular feedback mechanism.(ABSTRACT TRUNCATED AT 250 WORDS)
This article has been cited by other articles:
|
|
 |
|
  J. A. Jessup, P. E. Gallagher, D. B. Averill, K. B. Brosnihan, E. A. Tallant, M. C. Chappell, and C. M. Ferrario Effect of angiotensin II blockade on a new congenic model of hypertension derived from transgenic Ren-2 rats Am J Physiol Heart Circ Physiol, November 1, 2006; 291(5): H2166 - H2172. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. L. Opay, C. R. Mouton, J. J. Mullins, and K. D. Mitchell Cyclooxygenase-2 inhibition normalizes arterial blood pressure in CYP1A1-REN2 transgenic rats with inducible ANG II-dependent malignant hypertension Am J Physiol Renal Physiol, September 1, 2006; 291(3): F612 - F618. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. D Mitchell, S. J Bagatell, C. S Miller, C. R Mouton, D. M Seth, and J. J Mullins Genetic Clamping of Renin Gene Expression Induces Hypertension and Elevation of Intrarenal Ang II Levels of Graded Severity in Cyp1a1-Ren2 Transgenic Rats Journal of Renin-Angiotensin-Aldosterone System, June 1, 2006; 7(2): 74 - 86. [Abstract] [PDF]
|
|
|
|
|
|
K. D. Mitchell and J. J. Mullins Enhanced tubuloglomerular feedback in Cyp1a1-Ren2 transgenic rats with inducible ANG II-dependent malignant hypertension Am J Physiol Renal Physiol, December 1, 2005; 289(6): F1210 - F1216. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. E. Patterson, C. R. Mouton, J. J. Mullins, and K. D. Mitchell Interactive effects of superoxide anion and nitric oxide on blood pressure and renal hemodynamics in transgenic rats with inducible malignant hypertension Am J Physiol Renal Physiol, October 1, 2005; 289(4): F754 - F759. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. L. Howard, M. E. Patterson, J. J. Mullins, and K. D. Mitchell Salt-sensitive hypertension develops after transient induction of ANG II-dependent hypertension in Cyp1a1-Ren2 transgenic rats Am J Physiol Renal Physiol, April 1, 2005; 288(4): F810 - F815. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 L. CERVENKA, K. D. MITCHELL, and L. G. NAVAR Renal Function in Mice: Effects of Volume Expansion and AngiotensinII J. Am. Soc. Nephrol., December 1, 1999; 10(12): 2631 - 2636. [Abstract] [Full Text]
|
|
|
|
|
|
S. M. Jacinto, J. J. Mullins, and K. D. Mitchell Enhanced renal vascular responsiveness to angiotensin II in hypertensive ren-2 transgenic rats Am J Physiol Renal Physiol, February 1, 1999; 276(2): F315 - F322. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. Zhuo, M. Ohishi, and F. A. O. Mendelsohn Roles of AT1 and AT2 Receptors in the Hypertensive Ren-2 Gene Transgenic Rat Kidney Hypertension, January 1, 1999; 33(1): 347 - 353. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. Cervenka, C.-T. Wang, and L. G. Navar Effects of acute AT1 receptor blockade by candesartan on arterial pressure and renal function in rats Am J Physiol Renal Physiol, May 1, 1998; 274(5): F940 - F945. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. E. Springate, L. G. Feld, and D. Ganten Enalapril and Renal Function in Hypertensive Rats Transgenic for Mouse Renin Gene Hypertension, October 1, 1997; 30(4): 868 - 872. [Abstract] [Full Text]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
