AJP - Renal Physiology, Vol 268, Issue 5 907-F912, Copyright © 1995 by American Physiological Society

ARTICLES

Restoration of vasa recta hemodynamics and pressure natriuresis in SHR by L-arginine

T. S. Larson and J. C. Lockhart
Division of Nephrology and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

An increase in medullary blood flow has been implicated as a mediator of the natriuresis following increases in renal perfusion pressure (RPP). We examined whether administration of L-arginine, the substrate for nitric oxide production, restores the impaired vasa recta hemodynamic response to increases in RPP and the blunted pressure natriuresis of the spontaneously hypertensive rat (SHR). The response of descending (QDVR) and ascending vasa recta blood flow (QAVR) and of urinary sodium excretion (UNaV) was examined as RPP was increased by means of an adjustable aortic clamp placed above the renal arteries in young SHR and Wistar-Kyoto (WKY) rats. When RPP was increased in SHR receiving infusion of L-arginine (n = 7), QDVR and QAVR increased significantly in association with increases in UNaV. In SHR receiving the inactive enantiomer, D-arginine (n = 7), similar increases in RPP failed to increase QAVR and QDVR and were associated with an attenuated increase in UNaV. WKY animals infused with either D-arginine or L-arginine had increases in QDVR, QAVR, and UNaV in response to increases in RPP that were of similar magnitude to SHR receiving L-arginine. Thus the administration of L-arginine to SHR restores the pressure-dependent increases in renal medullary hemodynamics in association with restoration of pressure natriuresis.

This article has been cited by other articles:

				A. Sarkis, K. L. Liu, M. Lo, and D. Benzoni Angiotensin II and renal medullary blood flow in Lyon rats Am J Physiol Renal Physiol, February 1, 2003; 284(2): F365 - F372. [Abstract] [Full Text] [PDF]

				M.-G. Feng, S. A. W. Dukacz, and R. L. Kline Selective effect of tempol on renal medullary hemodynamics in spontaneously hypertensive rats Am J Physiol Regulatory Integrative Comp Physiol, November 1, 2001; 281(5): R1420 - R1425. [Abstract] [Full Text] [PDF]

				K. L. Rhinehart and T. L. Pallone Nitric oxide generation by isolated descending vasa recta Am J Physiol Heart Circ Physiol, July 1, 2001; 281(1): H316 - H324. [Abstract] [Full Text] [PDF]

				S. A. W. Dukacz, M.-G. Feng, L.-F. Yang, R. M. K. W. Lee, and R. L. Kline Abnormal renal medullary response to angiotensin II in SHR is corrected by long-term enalapril treatment Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2001; 280(4): R1076 - R1084. [Abstract] [Full Text] [PDF]

				A. Ichihara, M. Hayashi, N. Hirota, and T. Saruta Superoxide Inhibits Neuronal Nitric Oxide Synthase Influences on Afferent Arterioles in Spontaneously Hypertensive Rats Hypertension, February 1, 2001; 37(2): 630 - 634. [Abstract] [Full Text] [PDF]

				T. L. Pallone, E. P. Silldorff, and Z. Zhang Inhibition of calcium signaling in descending vasa recta endothelia by ANG II Am J Physiol Heart Circ Physiol, April 1, 2000; 278(4): H1248 - H1255. [Abstract] [Full Text] [PDF]

				W. J. Welch, A. Tojo, J.-U. Lee, D. G. Kang, C. G. Schnackenberg, and C. S. Wilcox Nitric oxide synthase in the JGA of the SHR: expression and role in tubuloglomerular feedback Am J Physiol Renal Physiol, July 1, 1999; 277(1): F130 - F138. [Abstract] [Full Text] [PDF]

				S. A. W. Dukacz, M. A. Adams, and R. L. Kline Short- and long-term enalapril affect renal medullary hemodynamics in the spontaneously hypertensive rat Am J Physiol Regulatory Integrative Comp Physiol, January 1, 1999; 276(1): R10 - R16. [Abstract] [Full Text] [PDF]

				T. L. Pallone, E. P. Silldorff, and J. Y. Cheung Response of isolated rat descending vasa recta to bradykinin Am J Physiol Heart Circ Physiol, March 1, 1998; 274(3): H752 - H759. [Abstract] [Full Text] [PDF]

				T. Disashi, H. Nonoguchi, T. Iwaoka, S. Naomi, Y. Nakayama, K. Shimada, K. Tanzawa, and K. Tomita Endothelin Converting Enzyme-1 Gene Expression in the Kidney of Spontaneously Hypertensive Rats Hypertension, December 1, 1997; 30(6): 1591 - 1597. [Abstract] [Full Text]