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Am J Physiol Renal Physiol 269: F110-F115, 1995;
0363-6127/95 $5.00
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AJP - Renal Physiology, Vol 269, Issue 1 110-F115, Copyright © 1995 by American Physiological Society

ARTICLES

Angiotensin II regulates nephrogenesis and renal vascular development

A. Tufro-McReddie, L. M. Romano, J. M. Harris, L. Ferder and R. A. Gomez
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville 22908, USA.

To test the hypothesis that angiotensin II (ANG II) is necessary for normal embryonic and postnatal kidney development, the effect of angiotensin receptor blockade or angiotensin converting enzyme inhibition on nephrovascular development was studied in newborn Sprague-Dawley rats and in Rana catesbeiana tadpoles undergoing prometamorphosis. Blockade of ANG II type 1 receptor (AT1) in newborn rats induced an arrest in nephrovascular maturation and renal growth, resulting in altered kidney architecture, characterized by fewer, thicker, and shorter afferent arterioles, reduced glomerular size and number, and tubular dilatation. Inhibition of ANG II generation in tadpoles induced even more marked developmental renal abnormalities. Blockade of ANG II type 2 receptor (AT2) in newborn rats did not alter renal growth or morphology. Results indicate that ANG II regulates nephrovascular development, a role that is conserved across species.


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