AJP - Renal AJP: Renal Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 269: F134-F139, 1995;
0363-6127/95 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Beierwaltes, W. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Beierwaltes, W. H.

AJP - Renal Physiology, Vol 269, Issue 1 134-F139, Copyright © 1995 by American Physiological Society

ARTICLES

Selective neuronal nitric oxide synthase inhibition blocks furosemide-stimulated renin secretion in vivo

W. H. Beierwaltes
Hypertension and Vascular Research Division, Henry Ford Hospital, Detroit, Michigan 48202, USA.

The macula densa is a regulatory site for renin. It contains exclusively the neuronal isoform of nitric oxide synthase (NOS), suggesting NO could stimulate renin secretion through the macula densa pathway. To test whether neuronal NOS mediates renin secretion, renin was stimulated by either the renal baroreceptor or the diuretic furosemide (acting through the macula densa pathway). Renin secretion rate (RSR) was measured in 12 Inactin-anesthetized rats at normal (104 +/- 3 mmHg) and reduced renal perfusion pressure (65 +/- 1 mmHg), before and after selective blockade of the neuronal NOS with 7-nitroindazole (7-NI, 50 mg/kg ip). 7-NI had no effect on basal blood pressure (102 +/- 2 mmHg) or renal blood flow (RBF). Decreasing renal perfusion pressure doubled RSR from 11.8 +/- 3.3 to 22.9 +/- 5.7 ng ANG I.h-1.min-1 (P < 0.01) (ANG I is angiotensin I). Similarly, in 7-NI-treated rats, reduced perfusion doubled RSR from 8.5 +/- 1.8 to 20.5 +/- 6.2 ng ANG I.h-1.min-1 (P < 0.01). Renal hemodynamics and RSR were measured in response to 5 mg/kg iv furosemide in 12 control rats and 11 rats treated with 7-NI. Blocking neuronal NOS did not alter blood pressure (102 +/- 2 mmHg), RBF (5.8 +/- 0.4 ml.min-1.g kidney wt-1), or renal vascular resistance (18.7 +/- 1.4 mmHg.ml-1.min.g kidney wt).(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
E. Kompanowska-Jezierska, H. Wolff, M. Kuczeriszka, J. B. Gramsbergen, A. Walkowska, E. J. Johns, and P. Bie
Renal nerves and nNOS: roles in natriuresis of acute isovolumetric sodium loading in conscious rats
Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2008; 294(4): R1130 - R1139.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
H. M. Siragy, T. Inagami, and R. M. Carey
NO and cGMP mediate angiotensin AT2 receptor-induced renal renin inhibition in young rats
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2007; 293(4): R1461 - R1467.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
L. M. Yamaleyeva, P. E. Gallagher, S. Vinsant, and M. C. Chappell
Discoordinate regulation of renal nitric oxide synthase isoforms in ovariectomized mRen2.Lewis rats
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2007; 292(2): R819 - R826.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
W. H. Beierwaltes
cGMP stimulates renin secretion in vivo by inhibiting phosphodiesterase-3
Am J Physiol Renal Physiol, June 1, 2006; 290(6): F1376 - F1381.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
D. L. Mattson and C. J. Meister
Renal cortical and medullary blood flow responses to L-NAME and ANG II in wild-type, nNOS null mutant, and eNOS null mutant mice
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R991 - R997.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. C. Thomson, A. Deng, N. Komine, J. S. Hammes, R. C. Blantz, and F. B. Gabbai
Early diabetes as a model for testing the regulation of juxtaglomerular NOS I
Am J Physiol Renal Physiol, October 1, 2004; 287(4): F732 - F738.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Paliege, D. Mizel, C. Medina, A. Pasumarthy, Y. G. Huang, S. Bachmann, J. P. Briggs, J. B. Schnermann, and T. Yang
Inhibition of nNOS expression in the macula densa by COX-2-derived prostaglandin E2
Am J Physiol Renal Physiol, July 1, 2004; 287(1): F152 - F159.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H. Castrop, F. Schweda, D. Mizel, Y. Huang, J. Briggs, A. Kurtz, and J. Schnermann
Permissive role of nitric oxide in macula densa control of renin secretion
Am J Physiol Renal Physiol, May 1, 2004; 286(5): F848 - F857.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
J. C. Sullivan, A. D. Giulumian, D. M. Pollock, L. C. Fuchs, and J. S. Pollock
Functional NOS 1 in the rat mesenteric arterial bed
Am J Physiol Heart Circ Physiol, August 1, 2002; 283(2): H658 - H663.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
W. H. Beierwaltes
Cyclooxygenase-2 products compensate for inhibition of nitric oxide regulation of renal perfusion
Am J Physiol Renal Physiol, July 1, 2002; 283(1): F68 - F72.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. M. Sayago and W. H. Beierwaltes
Nitric oxide synthase and cGMP-mediated stimulation of renin secretion
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2001; 281(4): R1146 - R1151.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Kakoki, A.-P. Zou, and D. L. Mattson
The influence of nitric oxide synthase 1 on blood flow and interstitial nitric oxide in the kidney
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2001; 281(1): R91 - R97.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. C. Harris and M. D. Breyer
Physiological regulation of cyclooxygenase-2 in the kidney
Am J Physiol Renal Physiol, July 1, 2001; 281(1): F1 - F11.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Endocrinol. Metab.Home page
A. Charbonneau, M. Leclerc, and M. G. Brunette
Effect of angiotensin II on calcium reabsorption by the luminal membranes of the nephron
Am J Physiol Endocrinol Metab, June 1, 2001; 280(6): E928 - E936.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
W. Weichert, A. Paliege, A. P. Provoost, and S. Bachmann
Upregulation of juxtaglomerular NOS1 and COX-2 precedes glomerulosclerosis in fawn-hooded hypertensive rats
Am J Physiol Renal Physiol, April 1, 2001; 280(4): F706 - F714.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
L. Xu, E. P. Carter, M. Ohara, P.-Y. Martin, B. Rogachev, K. Morris, M. Cadnapaphornchai, M. Knotek, and R. W. Schrier
Neuronal nitric oxide synthase and systemic vasodilation in rats with cirrhosis
Am J Physiol Renal Physiol, December 1, 2000; 279(6): F1110 - F1115.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
H.-F. Cheng, J.-L. Wang, M.-Z. Zhang, James. A. McKanna, and R. C. Harris
Nitric oxide regulates renal cortical cyclooxygenase-2 expression
Am J Physiol Renal Physiol, July 1, 2000; 279(1): F122 - F129.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
R. Komers, T. T. Oyama, J. G. Chapman, K. M. Allison, and S. Anderson
Effects of Systemic Inhibition of Neuronal Nitric Oxide Synthase in Diabetic Rats
Hypertension, February 1, 2000; 35(2): 655 - 661.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Lung Cell. Mol. Physiol.Home page
R. L. Rairigh, L. Storme, T. A. Parker, T. D. le Cras, N. Markham, M. Jakkula, and S. H. Abman
Role of neuronal nitric oxide synthase in regulation of vascular and ductus arteriosus tone in the ovine fetus
Am J Physiol Lung Cell Mol Physiol, January 1, 2000; 278(1): L105 - L110.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D. L. Mattson and F. Wu
Nitric Oxide Synthase Activity and Isoforms in Rat Renal Vasculature
Hypertension, January 1, 2000; 35(1): 337 - 341.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
B. Braam
Renal endothelial and macula densa NOS: integrated response to changes in extracellular fluid volume
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1551 - R1561.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
H. M. Stauss, A. Godecke, R. Mrowka, J. Schrader, and P. B. Persson
Enhanced Blood Pressure Variability in eNOS Knockout Mice
Hypertension, June 1, 1999; 33(6): 1359 - 1363.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
D. Y. Tan, S. Meng, and R. D. Manning Jr
Role of Neuronal Nitric Oxide Synthase in Dahl Salt-Sensitive Hypertension
Hypertension, January 1, 1999; 33(1): 456 - 461.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Kurtz and C. Wagner
Role of nitric oxide in the control of renin secretion
Am J Physiol Renal Physiol, December 1, 1998; 275(6): F849 - F862.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
R. Zatz and C. Baylis
Chronic Nitric Oxide Inhibition Model Six Years On
Hypertension, December 1, 1998; 32(6): 958 - 964.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
X. Wang, M. Lu, Y. Gao, A. Papapetropoulos, W. C. Sessa, and W. Wang
Neuronal nitric oxide synthase is expressed in principal cell of collecting duct
Am J Physiol Renal Physiol, September 1, 1998; 275(3): F395 - F399.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
C. S. Wilcox, X. Deng, and W. J. Welch
NO generation and action during changes in salt intake: roles of nNOS and macula densa
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1998; 274(6): R1588 - R1593.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Lu, X. Wang, and W. Wang
Nitric oxide increases the activity of the apical 70-pS K+ channel in TAL of rat kidney
Am J Physiol Renal Physiol, May 1, 1998; 274(5): F946 - F950.
[Abstract] [Full Text] [PDF]

Home page
 Proc. Natl. Acad. Sci. USAHome page
A. Kurtz, K.-H. Gotz, M. Hamann, and C. Wagner
Stimulation of renin secretion by nitric oxide is mediated by phosphodiesterase 3
PNAS, April 14, 1998; 95(8): 4743 - 4747.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Kurtz, K.-H. Gotz, M. Hamann, M. Kieninger, and C. Wagner
Stimulation of renin secretion by NO donors is related to the cAMP pathway
Am J Physiol Renal Physiol, April 1, 1998; 274(4): F709 - F717.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
N. A. Bobadilla, G. Gamba, E. Tapia, R. Garcia-Torres, A. Bolio, P. Lopez-Zetina, and J. Herrera-Acosta
Role of NO in cyclosporin nephrotoxicity: effects of chronic NO inhibition and NO synthases gene expression
Am J Physiol Renal Physiol, April 1, 1998; 274(4): F791 - F798.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
A. Ichihara, E. W. Inscho, J. D. Imig, and L. G. Navar
Neuronal nitric oxide synthase modulates rat renal microvascular function
Am J Physiol Renal Physiol, March 1, 1998; 274(3): F516 - F524.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
J. Schnermann
Juxtaglomerular cell complex in the regulation of renal salt excretion
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 1998; 274(2): R263 - R279.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Zuckerman, P. N. Chander, G. A. Zeballos, and C. T. Stier Jr
Regional Renal Nitric Oxide Release in Stroke-Prone Spontaneously Hypertensive Rats
Hypertension, December 1, 1997; 30(6): 1479 - 1486.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Renal Physiol.Home page
W. H. Beierwaltes, D'A. L. Potter, and E. G. Shesely
Renal baroreceptor-stimulated renin in the eNOS knockout mouse
Am J Physiol Renal Physiol, January 1, 2002; 282(1): F59 - F64.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online