| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
|
|
|
|||||||
|
|||||||||
AJP - Renal Physiology, Vol 269, Issue 6 876-F883, Copyright © 1995 by American Physiological Society
ARTICLES |
V. Vallon, R. C. Blantz and S. Thomson
Department of Medicine, University of California San Diego, USA.
We tested the hypothesis that the ability of the tubuloglomerular feedback (TGF) to stabilize renal function is impaired in rats with 7-8 wk of insulin-treated streptozotocin-diabetes. Proximal tubular flow was measured in free-flowing nephrons using a noninvasive optical technique. The homeostatic efficiency of TGF was determined from the fractional compensation for perturbations in ambient flow. Fractional compensation was substantially reduced in diabetic rats. To assess the roles of the proximal tubule and loop of Henle as determinants of TGF efficiency, we tested the effect of diabetes on proximal tubular reabsorption as determined by standard micropuncture and on the ionic content of early distal tubular fluid by employing a microelectrode for on-line measurement of electrical conductivity (TED). Diabetes caused glomerular hyperfiltration and increased fractional proximal tubular reabsorption (FPR), such that late proximal tubular flow (VLP) and early distal tubular flow were unaffected. The increase in FPR was a minor contributor to the overall effect on fractional compensation. Diabetes decreased the ambient TED without affecting the slope of the relationship between VLP and TED. These results demonstrate that the homeostatic, efficiency of the TGF system is reduced in diabetes and that this cannot be fully accounted for by changes in tubular reabsorption. Impaired TGF efficiency renders the diabetic glomerular microvasculature more susceptible to impact from fluctuations in systemic hemodynamics.
This article has been cited by other articles:
|
|
 |
|
  C. M. Miracle, T. Rieg, H. Mansoury, V. Vallon, and S. C. Thomson Ornithine decarboxylase inhibitor eliminates hyperresponsiveness of the early diabetic proximal tubule to dietary salt Am J Physiol Renal Physiol, October 1, 2008; 295(4): F995 - F1002. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Z. Levine, M. Iacovitti, and S. J. Robertson Modulation of single-nephron GFR in the db/db mouse model of type 2 diabetes mellitus. II. Effects of renal mass reduction Am J Physiol Regulatory Integrative Comp Physiol, June 1, 2008; 294(6): R1840 - R1846. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Faulhaber-Walter, L. Chen, M. Oppermann, S. M. Kim, Y. Huang, N. Hiramatsu, D. Mizel, H. Kajiyama, P. Zerfas, J. P. Briggs, et al. Lack of A1 Adenosine Receptors Augments Diabetic Hyperfiltration and Glomerular Injury J. Am. Soc. Nephrol., April 1, 2008; 19(4): 722 - 730. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. Satriano, L. Wead, A. Cardus, A. Deng, G. R. Boss, S. C. Thomson, and R. C. Blantz Regulation of ecto-5'-nucleotidase by NaCl and nitric oxide: potential roles in tubuloglomerular feedback and adaptation Am J Physiol Renal Physiol, November 1, 2006; 291(5): F1078 - F1082. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Vallon, B. Muhlbauer, and H. Osswald Adenosine and kidney function. Physiol Rev, July 1, 2006; 86(3): 901 - 940. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Z. Levine, M. Iacovitti, S. J. Robertson, and G. A. Mokhtar Modulation of single-nephron GFR in the db/db mouse model of type 2 diabetes mellitus Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2006; 290(4): R975 - R981. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Thomson, A. Deng, N. Komine, J. S. Hammes, R. C. Blantz, and F. B. Gabbai Early diabetes as a model for testing the regulation of juxtaglomerular NOS I Am J Physiol Renal Physiol, October 1, 2004; 287(4): F732 - F738. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. C. Thomson, V. Vallon, and R. C. Blantz Kidney function in early diabetes: the tubular hypothesis of glomerular filtration Am J Physiol Renal Physiol, January 1, 2004; 286(1): F8 - F15. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 V. Vallon Tubuloglomerular Feedback and the Control of Glomerular Filtration Rate Physiology, August 1, 2003; 18(4): 169 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Komers and S. Anderson Paradoxes of nitric oxide in the diabetic kidney Am J Physiol Renal Physiol, June 1, 2003; 284(6): F1121 - F1137. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Vallon, D.-Y. Huang, A. Deng, K. Richter, R. C. Blantz, and S. Thomson Salt-Sensitivity of Proximal Reabsorption Alters Macula Densa Salt and Explains the Paradoxical Effect of Dietary Salt on Glomerular Filtration Rate in Diabetes Mellitus J. Am. Soc. Nephrol., July 1, 2002; 13(7): 1865 - 1871. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. M. Fitzgerald and M. W. Brands Nitric oxide may be required to prevent hypertension at the onset of diabetes Am J Physiol Endocrinol Metab, October 1, 2000; 279(4): E762 - E768. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. Komers, J. N. Lindsley, T. T. Oyama, K. M. Allison, and S. Anderson Role of neuronal nitric oxide synthase (NOS1) in the pathogenesis of renal hemodynamic changes in diabetes Am J Physiol Renal Physiol, September 1, 2000; 279(3): F573 - F583. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. Lang, K. Klingel, C. A. Wagner, C. Stegen, S. Warntges, B. Friedrich, M. Lanzendorfer, J. Melzig, I. Moschen, S. Steuer, et al. Deranged transcriptional regulation of cell-volume-sensitive kinase hSGK in diabetic nephropathy PNAS, July 5, 2000; 97(14): 8157 - 8162. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M. BAK, K. THOMSEN, T. CHRISTIANSEN, and A. FLYVBJERG Renal Enlargement Precedes Renal Hyperfiltration in Early Experimental Diabetes in Rats J. Am. Soc. Nephrol., July 1, 2000; 11(7): 1287 - 1292. [Abstract] [Full Text]
|
|
|
|
|
|
V. Vallon, J.-R. Schwark, K. Richter, and M. Hropot Role of Na+/H+ exchanger NHE3 in nephron function: micropuncture studies with S3226, an inhibitor of NHE3 Am J Physiol Renal Physiol, March 1, 2000; 278(3): F375 - F379. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Komers, T. T. Oyama, J. G. Chapman, K. M. Allison, and S. Anderson Effects of Systemic Inhibition of Neuronal Nitric Oxide Synthase in Diabetic Rats Hypertension, February 1, 2000; 35(2): 655 - 661. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. VALLON, K. RICHTER, R. C. BLANTZ, S. THOMSON, and H. OSSWALD Glomerular Hyperfiltration in Experimental Diabetes Mellitus: Potential Role of Tubular Reabsorption J. Am. Soc. Nephrol., December 1, 1999; 10(12): 2569 - 2576. [Abstract] [Full Text]
|
|
|
|
 |
|
 V. Vallon, M. Albinus, and D. Blach Effect of KATP Channel Blocker U37883A on Renal Function in Experimental Diabetes Mellitus in Rats J. Pharmacol. Exp. Ther., September 1, 1998; 286(3): 1215 - 1221. [Abstract] [Full Text]
|
|
|
|
|
|
L. A. Slomowitz, A. Deng, J. S. Hammes, F. Gabbai, and S. C. Thomson Glomerulotubular balance, dietary protein, and the renal response to glycine in diabetic rats Am J Physiol Regulatory Integrative Comp Physiol, April 1, 2002; 282(4): R1096 - R1103. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Scherzer and M. M. Popovtzer Segmental localization of mRNAs encoding Na+-K+-ATPase alpha 1- and beta 1-subunits in diabetic rat kidneys using RT-PCR Am J Physiol Renal Physiol, March 1, 2002; 282(3): F492 - F500. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
| Visit Other APS Journals Online |
