AJP - Renal Ad Instruments
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 273: F849-F856, 1997;
0363-6127/97 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Khundmiri, S. J.
Right arrow Articles by Yusufi, A. N. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Khundmiri, S. J.
Right arrow Articles by Yusufi, A. N. K.

AJP - Renal Physiology, Vol 273, Issue 6 849-F856, Copyright © 1997 by American Physiological Society

ARTICLES

Effect of reversible and irreversible ischemia on marker enzymes of BBM from renal cortical PT subpopulations

S. J. Khundmiri, M. Asghar, F. Khan, S. Salim and A. N. Yusufi
Department of Biochemistry, Faculty of Life Sciences, Aligarh Muslim University, India.

The effect of the reversible and relatively irreversible ischemia induced acute renal failure (ARF) in the activities of alkaline phosphatase (AlkPase) and gamma-glutamyltransferase (GGTase) after early (15-30 min) and prolonged (45-60 min) ischemia in the homogenates, and the brush-border membranes (BBM) from rat renal whole, superficial (SC), and juxtamedullary (JMC) cortices were studied. The enzyme activities declined progressively in proportion to the duration of ischemia. Early blood reflow of 15 min to the ischemic rats caused a further decrease in the enzyme activities. However, prolonged reflow (up to 120 min) resulted in partial reversal of the ischemic effect in the early but not in the prolonged ischemic rats. The decrease in the enzyme activities was due to the loss of membrane-bound enzyme components from the damaged BBM into the supernatant fraction as membrane-free enzymes. The activities of AlkPase and GGTase were significantly more decreased by the ischemia in the brush-border membrane vesicles (BBMV)-JMC than in BBMV-SC. The rate of recovery due to reflow for AlkPase was greater in BBMV-SC than apparently for GGTase in BBMV-JMC in early ischemic (15-30 min) rats.


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
E. Leal-Pinto, A. Teixeira, B. Tran, B. Hanss, and P. E. Klotman
Presence of the nucleic acid channel in renal brush-border membranes: allosteric modulation by extracellular calcium
Am J Physiol Renal Physiol, July 1, 2005; 289(1): F97 - F106.
[Abstract] [Full Text] [PDF]

Home page
 Hum Exp ToxicolHome page
S. Fatima, A. N. K. Yusufi, and R. Mahmood
Effect of cisplatin on renal brush border membrane enzymes and phosphate transport
Human and Experimental Toxicology, December 1, 2004; 23(12): 547 - 554.
[Abstract] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online