AJP - Renal Journal of Neurophysiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 274: F799-F804, 1998;
0363-6127/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Chan, C. M.
Right arrow Articles by Burnstock, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Chan, C. M.
Right arrow Articles by Burnstock, G.
Vol. 274, Issue 4, F799-F804, April 1998

RAPID COMMUNICATION
Localization of P2X1 purinoceptors by autoradiography and immunohistochemistry in rat kidneys

C. M. Chan1, R. J. Unwin1, M. Bardini2, I. B. Oglesby3, A. P. D. W. Ford3, A. Townsend-Nicholson2, and G. Burnstock2

1 Centre for Nephrology, Department of Medicine and 2 Department of Anatomy and Developmental Biology, University College London, London WC1E 6BT, United Kingdom; and 3 Roche Bioscience, Palo Alto, California 94304

P2 receptors have been identified in rat kidney by autoradiography, using the radioligand [3H]alpha ,beta -methylene ATP, and by immunohistochemistry, using a polyclonal antibody to the P2X1 purinoceptor. They have been localized to the vascular smooth muscle of intrarenal arteries, including arcuate and interlobular arteries, and afferent arterioles, but not glomeruli, postglomerular efferent arterioles, or renal tubules. We conclude that at least some of the P2 receptors present on vascular smooth muscle are of the P2X1 subtype. The functional significance of these findings in the vascular control of the kidney is discussed.

immunohistochemistry; adenosine 5'-triphosphate


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Oppermann, D. J. Friedman, R. Faulhaber-Walter, D. Mizel, H. Castrop, K. Enjyoji, S. C. Robson, and J. Schnermann
Tubuloglomerular feedback and renin secretion in NTPDase1/CD39-deficient mice
Am J Physiol Renal Physiol, April 1, 2008; 294(4): F965 - F970.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. L. Graciano, A. Nishiyama, K. Jackson, D. M. Seth, R. M. Ortiz, M. C. Prieto-Carrasquero, H. Kobori, and L. G. Navar
Purinergic receptors contribute to early mesangial cell transformation and renal vessel hypertrophy during angiotensin II-induced hypertension
Am J Physiol Renal Physiol, January 1, 2008; 294(1): F161 - F169.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
A. Nishiyama, K. E. Jackson, D. S. A. Majid, M. Rahman, and L. G. Navar
Renal interstitial fluid ATP responses to arterial pressure and tubuloglomerular feedback activation during calcium channel blockade
Am J Physiol Heart Circ Physiol, February 1, 2006; 290(2): H772 - H777.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
B. K. Kishore, J. Isaac, M. Fausther, S. R. Tripp, H. Shi, P. S. Gill, N. Braun, H. Zimmermann, J. Sevigny, and S. C. Robson
Expression of NTPDase1 and NTPDase2 in murine kidney: relevance to regulation of P2 receptor signaling
Am J Physiol Renal Physiol, May 1, 2005; 288(5): F1032 - F1043.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S.-L. Xia, L. Wang, M. N. Cash, X. Teng, R. A. Schwalbe, and C. S. Wingo
Extracellular ATP-induced calcium signaling in mIMCD-3 cells requires both P2X and P2Y purinoceptors
Am J Physiol Renal Physiol, August 1, 2004; 287(2): F204 - F214.
[Abstract] [Full Text] [PDF]

Home page
 J. Appl. Physiol.Home page
T. J. Bivalacqua, H. C. Champion, M. K. Shah, B. J. De Witt, E. W. Inscho, and P. J. Kadowitz
Comparative responses to alpha ,beta -methylene-ATP in cat pulmonary, mesenteric, and hindquarter vascular beds
J Appl Physiol, October 1, 2002; 93(4): 1287 - 1295.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
R. A. North
Molecular Physiology of P2X Receptors
Physiol Rev, October 1, 2002; 82(4): 1013 - 1067.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Nishiyama and L. G. Navar
ATP mediates tubuloglomerular feedback
Am J Physiol Regulatory Integrative Comp Physiol, July 1, 2002; 283(1): R273 - R275.
[Full Text] [PDF]

Home page
 Am. J. Physiol. Heart Circ. Physiol.Home page
X. Zhao, E. W. Inscho, M. Bondlela, J. R. Falck, and J. D. Imig
The CYP450 hydroxylase pathway contributes to P2X receptor-mediated afferent arteriolar vasoconstriction
Am J Physiol Heart Circ Physiol, November 1, 2001; 281(5): H2089 - H2096.
[Abstract] [Full Text] [PDF]

Home page
 J. Pharmacol. Exp. Ther.Home page
O. Cinkilic, B. F. King, M. van der Giet, H. Schluter, W. Zidek, and G. Burnstock
Selective Agonism of Group I P2X Receptors by Dinucleotides Dependent on a Single Adenine Moiety
J. Pharmacol. Exp. Ther., October 1, 2001; 299(1): 131 - 136.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
R. T. Worrell, H.-F. Bao, D. D. Denson, and D. C. Eaton
Contrasting effects of cPLA2 on epithelial Na+ transport
Am J Physiol Cell Physiol, July 1, 2001; 281(1): C147 - C156.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
E. W. Inscho
P2 receptors in regulation of renal microvascular function
Am J Physiol Renal Physiol, June 1, 2001; 280(6): F927 - F944.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
E. M. Schwiebert and B. K. Kishore
Extracellular nucleotide signaling along the renal epithelium
Am J Physiol Renal Physiol, June 1, 2001; 280(6): F945 - F963.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
S. M. White, J. D. Imig, T.-T. Kim, B. C. Hauschild, and E. W. Inscho
Calcium signaling pathways utilized by P2X receptors in freshly isolated preglomerular MVSMC
Am J Physiol Renal Physiol, June 1, 2001; 280(6): F1054 - F1061.
[Abstract] [Full Text] [PDF]

Home page
 Pharmacol. Rev.Home page
B. S. Khakh, G. Burnstock, C. Kennedy, B. F. King, R. A. North, P. Seguela, M. Voigt, and P. P. A. Humphrey
International Union of Pharmacology. XXIV. Current Status of the Nomenclature and Properties of P2X Receptors and Their Subunits
Pharmacol. Rev., March 1, 2001; 53(1): 107 - 118.
[Abstract] [Full Text] [PDF]

Home page
 HypertensionHome page
A. Nishiyama, D. S. A. Majid, M. Walker III, A. Miyatake, and L. G. Navar
Renal Interstitial ATP Responses to Changes in Arterial Pressure During Alterations in Tubuloglomerular Feedback Activity
Hypertension, February 1, 2001; 37(2): 753 - 759.
[Abstract] [Full Text] [PDF]

Home page
 Circ. Res.Home page
A. Nishiyama, D. S. A. Majid, K. A. Taher, A. Miyatake, and L. G. Navar
Relation Between Renal Interstitial ATP Concentrations and Autoregulation-Mediated Changes in Renal Vascular Resistance
Circ. Res., March 31, 2000; 86(6): 656 - 662.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
E. W. Inscho, A. C. Schroeder, P. C. Deichmann, and J. D. Imig
ATP-mediated Ca2+ signaling in preglomerular smooth muscle cells
Am J Physiol Renal Physiol, March 1, 1999; 276(3): F450 - F456.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
E. W. Inscho, A. K. Cook, V. Mui, and J. Miller
Direct assessment of renal microvascular responses to P2-purinoceptor agonists
Am J Physiol Renal Physiol, April 1, 1998; 274(4): F718 - F727.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Cell Physiol.Home page
L. M. Schwiebert, W. C. Rice, B. A. Kudlow, A. L. Taylor, and E. M. Schwiebert
Extracellular ATP signaling and P2X nucleotide receptors in monolayers of primary human vascular endothelial cells
Am J Physiol Cell Physiol, February 1, 2002; 282(2): C289 - C301.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
E. W. Inscho and A. K. Cook
P2 receptor-mediated afferent arteriolar vasoconstriction during calcium blockade
Am J Physiol Renal Physiol, February 1, 2002; 282(2): F245 - F255.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
E. M. Schwiebert, D. P. Wallace, G. M. Braunstein, S. R. King, J. Peti-Peterdi, K. Hanaoka, W. B. Guggino, L. M. Guay-Woodford, P. D. Bell, L. P. Sullivan, et al.
Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys
Am J Physiol Renal Physiol, April 1, 2002; 282(4): F763 - F775.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online