AJP - Renal Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 274: F883-F888, 1998;
0363-6127/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Shah, M.
Right arrow Articles by Baum, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shah, M.
Right arrow Articles by Baum, M.
Vol. 274, Issue 5, F883-F888, May 1998

Maturation of rabbit proximal straight tubule chloride/base exchange

Mehul Shah, Raymond Quigley, and Michel Baum

Department of Pediatrics and Internal Medicine, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75235-9063

The present in vitro microperfusion study compared the mechanism and rates of NaCl transport in neonatal and adult rabbit proximal straight tubules. In proximal straight tubules perfused with a late proximal tubular fluid and bathed in a serumlike albumin solution, the rate of volume absorption (JV) was 0.54 ± 0.10 and 0.12 ± 0.05 nl · mm-1 · min-1 in adults and neonates, respectively (P < 0.05). With the addition of 10-5 M bath ouabain, JV decreased to 0.27 ± 0.07 and -0.03 ± 0.04 nl · mm-1 · min-1 in adult and neonatal tubules, respectively (P < 0.05), consistent with lower rates of active and passive NaCl transport in the neonatal proximal straight tubule. The effect of luminal sodium and chloride removal on intracellular pH was used to assess the relative rates of Na+/H+ and Cl-/base exchange. The rates of Na+/H+ and Cl-/base exchange were approximately fivefold less in neonatal proximal straight tubules than adult tubules. In both neonatal and adult proximal straight tubules, the rate of Cl-/base exchange was not affected by formate, bicarbonate, or cyanide and acetazolamide, consistent with Cl-/OH- exchange. These data demonstrate an increase in proximal straight tubule NaCl transport during postnatal renal development.

renal development; intracellular pH; sodium chloride transport; sodium/proton antiporter


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
A. Dagan, J. Gattineni, V. Cook, and M. Baum
Prenatal programming of rat proximal tubule Na+/H+ exchanger by dexamethasone
Am J Physiol Regulatory Integrative Comp Physiol, March 1, 2007; 292(3): R1230 - R1235.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Baum and R. Quigley
Maturation of rat proximal tubule chloride permeability
Am J Physiol Regulatory Integrative Comp Physiol, December 1, 2005; 289(6): R1659 - R1664.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
N. Gupta, V. Dwarakanath, and M. Baum
Maturation of the Na+/H+ antiporter (NHE3) in the proximal tubule of the hypothyroid adrenalectomized rat
Am J Physiol Renal Physiol, September 1, 2004; 287(3): F521 - F527.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Baum and R. Quigley
Thyroid hormone modulates rabbit proximal straight tubule paracellular permeability
Am J Physiol Renal Physiol, March 1, 2004; 286(3): F477 - F482.
[Abstract] [Full Text]

Home page
 Am. J. Physiol. Renal Physiol.Home page
R. Quigley and M. Baum
Developmental changes in rabbit proximal straight tubule paracellular permeability
Am J Physiol Renal Physiol, September 1, 2002; 283(3): F525 - F531.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
C. A. Winkler, A. M. Kittelberger, R. H. Watkins, W. M. Maniscalco, and G. J. Schwartz
Maturation of carbonic anhydrase IV expression in rabbit kidney
Am J Physiol Renal Physiol, May 1, 2001; 280(5): F895 - F903.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Horster
Embryonic epithelial membrane transporters
Am J Physiol Renal Physiol, December 1, 2000; 279(6): F982 - F996.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Renal Physiol.Home page
M. Shah, R. Quigley, and M. Baum
Maturation of proximal straight tubule NaCl transport: role of thyroid hormone
Am J Physiol Renal Physiol, April 1, 2000; 278(4): F596 - F602.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
M. Shah, R. Quigley, and M. Baum
Neonatal rabbit proximal tubule basolateral membrane Na+/H+ antiporter and Cl-/base exchange
Am J Physiol Regulatory Integrative Comp Physiol, June 1, 1999; 276(6): R1792 - R1797.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online