AJP - Renal AJP: Heart and Circulatory Physiology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

Am J Physiol Renal Physiol 274: F1062-F1069, 1998;
0363-6127/98 $5.00
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Gimonet, V.
Right arrow Articles by Laborde, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Gimonet, V.
Right arrow Articles by Laborde, K.
Vol. 274, Issue 6, F1062-F1069, June 1998

Nephrogenesis and angiotensin II receptor subtypes gene expression in the fetal lamb

Valérie Gimonet, Laurence Bussieres, Anissa A. Medjebeur, Bernard Gasser, Brigitte Lelongt, and Kathleen Laborde

Department of Physiology, Necker-Enfants Malades Hospital, 75015 Paris, France

To investigate the role of angiotensin II (ANG II) in nephrogenesis, a developmental study of renal AT1 and AT2 receptor mRNA expression was performed in parallel with the quantitative and qualitative analysis of metanephros development in fetal lamb from 60 to 140 days of gestation. Both ANG II receptor subtypes were expressed early during nephrogenesis but displayed specific spatial and temporal distribution during gestation. High-AT2 mRNA expression took place in the outermost nephrogenic area and in the undifferentiated mesenchymal cells surrounding the ampulla; level of AT2 expression in this localization followed closely glomeruli proliferation rate and disappeared after nephrogenesis completion (>120 days). AT2 mRNA was also detected in the differentiated epithelial cells of macula densa of maturing glomeruli. Although most of AT1 mRNA labeling was found in the mesangial cells of maturing glomeruli, where it persisted after nephrogenesis completion, additional labeling was found in undifferentiated cells, in cells invading the inferior cleft of S-shaped bodies (80 days), and in medullar cells between tubules (120 days). Our results suggest that each receptor subtype has a specific role in renal morphogenesis, i.e., AT2 in mesenchymal proliferation or apoptosis and AT1 in vascular smooth muscle cells differentiation.

angiotensin II receptor expression; nephrogenesis; in situ hybridization; sheep


This article has been cited by other articles:


Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
V. Zohdi, K. M. Moritz, K. J. Bubb, M. L. Cock, N. Wreford, R. Harding, and M. J. Black
Nephrogenesis and the renal renin-angiotensin system in fetal sheep: effects of intrauterine growth restriction during late gestation
Am J Physiol Regulatory Integrative Comp Physiol, September 1, 2007; 293(3): R1267 - R1273.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. Rev.Home page
M. Paul, A. Poyan Mehr, and R. Kreutz
Physiology of local Renin-Angiotensin systems.
Physiol Rev, July 1, 2006; 86(3): 747 - 803.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. Chen, L. C. Carey, N. K. Valego, J. Liu, and J. C. Rose
Thyroid hormone modulates renin and ANG II receptor expression in fetal sheep
Am J Physiol Regulatory Integrative Comp Physiol, October 1, 2005; 289(4): R1006 - R1014.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. Chen, L. C. Carey, J. Liu, N. K. Valego, S. B. Tatter, and J. C. Rose
The effect of hypothalamo-pituitary disconnection on the renin-angiotensin system in the late-gestation fetal sheep
Am J Physiol Regulatory Integrative Comp Physiol, May 1, 2005; 288(5): R1279 - R1287.
[Abstract] [Full Text] [PDF]

Home page
 Am. J. Physiol. Regul. Integr. Comp. Physiol.Home page
K. Huber, U. Roesler, A. Muscher, K. Hansen, I. Widiyono, E. Pfeffer, and G. Breves
Ontogenesis of epithelial phosphate transport systems in goats
Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2003; 284(2): R413 - R421.
[Abstract] [Full Text] [PDF]

Home page
 Physiol. GenomicsHome page
M. PRIETO, S. DIPP, S. MELEG-SMITH, and S. S. EL-DAHR
Ureteric bud derivatives express angiotensinogen and AT1 receptors
Physiol Genomics, June 6, 2001; 6(1): 29 - 37.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online