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Am J Physiol Renal Physiol 274: F1119-F1126, 1998;
0363-6127/98 $5.00
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Vol. 274, Issue 6, F1119-F1126, June 1998

Cloning, renal distribution, and regulation of the rat Na+-HCOminus 3 cotransporter

Charles E. Burnham1, Michael Flagella2, Zhaohui Wang1, Hassane Amlal1, Gary E. Shull2, and Manoocher Soleimani2,3

Departments of 1 Medicine and 2 Molecular Genetics, Biochemistry, and Microbiology, University of Cincinnati School of Medicine, Cincinnati 45267-0585; and 3 Veterans Affairs Medical Centers at Cincinnati, Cincinnati, Ohio 45220

We recently reported the cloning and expression of a human kidney Na+-HCO-3 cotransporter (NBC-1) (C. E. Burnham, H. Amlal, Z. Wang, G. E. Shull, and M. Soleimani. J. Biol. Chem. 272: 19111-19114, 1997). To expedite in vivo experimentation, we now report the cDNA sequence of rat kidney NBC-1. In addition, we describe both the organ and nephron segment distributions and the regulation of NBC-1 mRNA under three models of pH stress: chloride-depletion alkalosis (CDA), metabolic acidosis, and bicarbonate loading. Rat NBC-1 cDNA encodes an open reading frame of 1,035 amino acids, with 96 and 87% identity to human and salamander NBC-1, respectively. Rat NBC-1 mRNA is expressed at high levels in kidney and brain, with lower levels in colon, stomach, and heart. None appears in liver. In the kidney, NBC-1 is expressed mainly in the proximal tubule, with traces found in medullary thick ascending limb and papilla. HCO-3 loading decreased NBC-1 mRNA levels, which were unchanged either by metabolic acidosis or by CDA.

proximal tubule; bicarbonate; acidosis; alkalosis


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